Postoperative Cognitive Dysfunction
Conditions
Keywords
Postoperative Cognitive Dysfunction, Cardiac Surgery, General Anesthesia, Neuropsychological Tests
Brief summary
This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.
Detailed description
The systemic inflammatory response after cardiac surgery may cause damage to the central nervous system and elevated markers of brain injury in peripheral blood. This event may be potentially related to the development of postoperative cognitive dysfunction (POCD), with incidences varying from 20 to 83%.
Interventions
None listed
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Maria José Carvalho Carmona
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients underwent for coronary artery bypass graft surgery
Exclusion criteria
* History of brain disease or dementia, other psychiatric disorders that affect cognition * Lack of proficiency in Portuguese language
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Score in Neuropsycological Tests | 1 year | Tests for evaluation of quality of life, depressive synths and neuropsycho;logical battery to assess general mental status, learning, attention, visuospatial perception, immediate memory, operational and executive ask and recall, including processing speed. This assessment will be applied before surgery, and 3, 7,21 90 and 180 days after surgery. |
Countries
Brazil
Contacts
Primary ContactMaria JC Carmona, M.D.
Backup ContactFernando CP Silva
Outcome results
None listed