Atrial Fibrillation, Stroke
Conditions
Brief summary
Recent studies demonstrated that prolonged rhythm observation increases the detection of atrial fibrillation in patients prior diagnosed as cryptogenic stroke. Detection of atrial fibrillation in these patients has important therapeutic implications for the anticoagulation regimen. However, data on optimal monitoring duration and method of AF detection are limited.
Interventions
None listed
Sponsors
Medisch Spectrum Twente
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \> 18 years of age Recent episode (≤60 days) of cryptogenic ischemic stroke * Undetermined etiology with negative evaluation (including cardioembolism work- up) according to the criteria for the Trial of Org 10172 in Acute Stroke Treatment (TOAST) * Implantation of an implantable loop recorder within two months after index event * Able of providing informed consent
Exclusion criteria
* Pre-existing indication for vitamin K antagonist * Untreated hyperthyroidism * Indication for pacemaker implantation, implantable cardioverter defibrillator (ICD) or Cardiac Resynchronisation Therapy (CRT) * Severe co-morbidity not likely to complete follow-up for one year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Documented Atrial Fibrillation (AF) | One year | The percentage of patients with documented AF based on implantable cardiac monitor registration during a follow-up period of at least 12 months after an episode of cryptogenic stroke. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to documented AF | One year | Time to documented AF using an Implantable Loop Recorder (ILR) data |
| Recurrent stroke | One year | Incidence of recurrent stroke |
Countries
Netherlands
Outcome results
None listed