Evaluation of the Cone Outer Segment Tips Line After Epiretinal Membrane Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01549249

Enrollment

333

Registered

2012-03-09

Start date

2008-06-30

Completion date

2011-11-30

Last updated

2012-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epiretinal Membrane

Keywords

cone outer segment tips line, inner segment/outer segment junction line, optical coherence tomography, epiretinal membrane

Brief summary

The recovery of the cone outer segment tips (COST) line after epiretinal membrane (ERM) surgery using spectral-domain optical coherence tomography (SD-OCT) was assessed.

Detailed description

Epiretinal membrane (ERM) may cause decreased central vision or metamorphopsia. Pars plana vitrectomy with membrane peeling has become the standard treatment for epiretinal membrane. However, visual recovery or symptomatic relief is not always satisfactory in all eyes despite successful membrane removal. Spectral domain optical coherence tomography (SD-OCT) is a non-invasive imaging device for various vitreoretinal diseases. Cone outer segment tips (COST) line is a line observed between IS/OS line and RPE in SD-OCT. The investigators examined the correlation of visual acuity and the recovery of photoreceptor layer after ERM surgery, taking COST line into account as a new parameter

Interventions

DEVICEoptical coherence tomography

spectral-domain optical coherence tomography

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

40 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patients who received epiretinal membrane surgery between June, 2008, and November, 2010, at Kyorin Eye Center. * Only eyes with postoperative follow-up period more than 6 months were included.

Exclusion criteria

* Eyes with secondary epiretinal membrane (previous history of uveitis, intraocular surgery, pre-operatively noted retinal breaks, etc.) were excluded.

Design outcomes

Primary

Measure	Time frame
best-corrected visual acuity	one year

Secondary

Measure	Time frame
Integrity and defect length of the photoreceptor layer detected by spectral-domain optical coherence tomography	one year

Countries

Japan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026