Comparison of the Effects of Sevoflurane and Midazolam Used for the Maintenance of Anaesthesia on the Levels of Postoperative Cardiac Troponin I in Pediatric Cardiac Surgery

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01548859

Enrollment

Registered

2012-03-08

Start date

2011-07-31

Completion date

2012-06-30

Last updated

2012-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthetic Preconditioning, Myocardial Injury

Keywords

Myocardial protection, Myocardial injury, Anaesthetic preconditioning, Pediatric cardiac surgery, Troponin I, Sevoflurane, Midazolam

Brief summary

The purpose of this study is to compare two different anaesthetic agent effect on postoperative Troponin I levels in pediatric cardiac surgery

Interventions

DRUGMidazolam

0.2 mg/kg/saat continuous infusion of midazolam received during anaesthesia

DRUGSevoflurane

end tidal concentration of % 0,5-8

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

1 Months to 6 Years

Healthy volunteers

Inclusion criteria

* Patients scheduled for elective pediatric surgery * Patients written informed consent for study participation

Exclusion criteria

* Redo surgery * History of myocarditis * Renal failure * Pulmonary embolism * Hypothyroidism

Design outcomes

Primary

Measure	Time frame	Description
myocardial protective effect of sevoflurane	postoperative 48 hours	Postoperative troponin I levels

Secondary

Measure	Time frame	Description
Hemodynamic and respiratory data	Postoperative 48 hours	Arterial pressure, heart rate, blood gas analysis, extubation time,

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026