Movement Disorders (Incl Parkinsonism), REM Sleep Behavior Disorder, Tremor Familial Essential, 1
Conditions
Brief summary
This proposal is focused on developing a reliable, valid, and reproducible imaging techniques and statistical methodology for segregation of various forms of Parkinsonism from healthy adults without Parkinsonism.
Detailed description
This proposal is focused on developing a reliable, valid, and reproducible imaging techniques and statistical methodology for segregation of various forms of Parkinsonism from healthy adults without Parkinsonism. We focus on early diagnosis of Parkinsonism, other tremor disorders, and determine how imaging might be used to improve diagnosis. The purpose of this protocol is to gather a multi-modal dataset to explore and validate the investigator's previous research findings in prior studies.
Interventions
None listed
Sponsors
University of Alabama at Birmingham
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy Control • Age 35-85 Parkinson Disease (PD) Age 35-85 Diagnosis of clinically definite PD made by a movement disorders specialist, with evidence of the following features: * Presence of bradykinesia and 1 or both of the following: 1. Rest tremor 2. Rigidity * Asymmetric Onset * Progressive motor symptoms * Levodopa responsive * Duration at least 1 but not more than 10 years * Hoehn and Yahr Stage 1-2 Progressive Supranuclear Palsy (PSP) Age 40-85 Diagnosis of clinically definite PSP, with the following features: * Gradually progressive disorder. * Onset after age 39 * Supranuclear palsy\* and postural instability with falls in the first year of disease onset\*. * No evidence of other disease. Parkinsonism of Other or Undetermined Cause (POC) Age 35-85 Diagnosis of parkinsonism of undetermined other other cause by a movement disorders specialist, with the following features: * Signs and symptoms of Parkinsonism including 1. Bradykinesia 2. Mixed or resting tremor 3. Rigidity 4. Characteristic deficits of gait and balance associated with Parkinsonism Essential Tremor (ET) Age 35-85 Diagnosis of essential tremor, with the following features: * A 2+ postural tremor of at least 1 arm (a head tremor may also be present, but is not sufficient for diagnosis) * On examination, there must be 1. a 2+ kinetic tremor during at least 4 tasks, or; 2. a 2+ kinetic tremor on 1 task and a 3+ kinetic tremor on a second task; tasks include pouring water, using a spoon to drink water, drinking water, finger-to-nose, and drawing a spiral * If on examination, the tremor is present in the dominant hand, then by report, it must interfere with at least 1 activity of daily living. REM Behavior Disorder (RBD) Age 25 - 85 Documented diagnosis of REM sleep behavior disorder (RBD) by a sleep medicine specialist, with the following clinical features: * Presence of REM sleep without atonia on polysomnography * At least one of the following conditions: 1. Sleep-related, behaviors by history (eg, dream enactment behavior) 2. Abnormal REM sleep behavior documented during PSG monitoring
Exclusion criteria
Healthy Control * Pregnancy * First-degree blood relative affected by PD * Neurodegenerative disease * History of repeated head injury, encephalitis, brain surgery, stroke, dementia, neuroleptic exposure, or serious medical illness that may interfere with participation. Parkinson Disease (PD) * Any
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI compared between cohorts | one time at initial visit | Studying resting brain activity between healthy adults, participants with Parkinson's and participants with REM Behavior Disorder. |
Countries
United States
Outcome results
None listed