Platelet Reactivity and MES During CEA

Platelet Reactivity Testing in Association With Perioperative Microembolic Signals During Carotid Endarterectomy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01547039

Enrollment

200

Registered

2012-03-07

Start date

2012-06-30

Completion date

2014-07-31

Last updated

2012-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aspirin Resistance, Carotid Artery Stenosis, Ischemic Stroke, Myocardial Infarction

Keywords

Carotid endarterectomy, Transcranial doppler, Micro embolic signals, Platelets, Aspirin

Brief summary

The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Al patients undergoing elective carotid endarterectomy

Exclusion criteria

* Patients requiring a blood transfusion prior to surgery * Patients with an inappropriate temporal bone window for transcranial Doppler (TCD) * Patients on vitamin K antagonists or antiplatelet treatment other then aspirin * Patients with an artificial cardiac valve

Design outcomes

Primary

Measure	Time frame	Description
Microembolic signals (MES)	During and 1 hour following carotid endarterectomy (CEA)	Microembolic signals detected by transcranial duplex (TCD)

Secondary

Measure	Time frame	Description
Ischemic stroke	within 30 days postoperative	—
Asymptomatic perioperative myocardial injury	3 days postoperative	Troponin elevation \> 0.1 ng/ml
Myocardial infarction	Within 30 days postoperative	—

Countries

Netherlands

Outcome results