Obesity, Obstructive Sleep Apnoea
Conditions
Keywords
exercise, diet, lifestyle, sleep apnoea, obesity
Brief summary
Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a common disorder characterised by interrupted breathing while sleeping. It is associated with cardiovascular problems such as high blood pressure, heart attack and stroke. Furthermore, most patients with OSAHS are overweight and have impaired quality of life. Lifestyle interventions incorporating exercise training, dietary advice and behaviour change have been shown to elicit favourable changes in quality of life, body mass/composition and cardiovascular risk in a range of patient groups. However, no study has investigated the impact of lifestyle modification on such health outcomes in patients with OSAHS. This study will address this issue by investigating the effects of a lifestyle intervention on quality of life, body mass/composition and cardiovascular risk in patients with OSAHS. A total of 60 volunteers will be recruited and randomly allocated to one of the two groups. Patients in the intervention group will be offered a 12-week individualised lifestyle programme consisting of supervised exercise training, dietary advice and behaviour change counselling. Patients in the control group will receive an educational booklet detailing healthy eating and exercise guidelines but no supervised or structured intervention. The results of this study will inform the design of a larger, multi-centre randomised controlled trial.
Interventions
BEHAVIORALCombined lifestyle intervention
Exercise training, dietary advice, behaviour change counselling
Sponsors
Sheffield Hallam University
Sheffield Teaching Hospitals NHS Foundation Trust
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* obstructive sleep apnoea patients who have been receiving CPAP therapy for at least 6 months and are known to be adherent to the treatment (\>75% nightly use per week) * clinically obese (body mass index \>30) * age 18-85 years * able to undertake exercise testing and training
Exclusion criteria
* patients with any contraindications to exercise (e.g. severe hypertension, unstable arrhythmias, severe musculoskeletal injuries) * unable to undertake the requirements of the study * non-English speaking * already undertaking \>30 min exercise \>3 times per week * non-compliant with CPAP * body mass index \<30 * unable to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass | 25 weeks |
| Incremental shuttle walk performance | 25 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life (EQ-5D and EQ-VAS) | 13 and 25 weeks |
| Body fat percentage | 13 and 25 weeks |
| Resting blood pressure | 13 and 25 weeks |
| Blood markers (glucose, insulin, lipids, CRP) | 13 and 25 weeks |
Countries
United Kingdom
Outcome results
None listed