Acute Pain Management, Renal Colic
Conditions
Brief summary
The purpose of this study is to determine whether sublingual Buprenorphine is as effective as Iv Morphine sulfate on pain control of the patients with acute renal colic in the emergency department.
Interventions
DRUGBuprenorphine
2 mg sublingual tablet
DRUGMorphine
0.1 mg/kg IV morphine
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* clinical diagnosis of acute renal colic; positive urinalysis of hematuria; pain score more than 3 in Numerical Rating Score (NRS); patients sign the informed consent to enroll.
Exclusion criteria
* previous history of seizures; cardiovascular, hepatic, renal or metabolic diseases; * febrile patients (T \> 38°C); * hemodynamically unstable patients ( Systolic Blood Pressure \< 90 mmHg); * pregnant patients; * patients with abdominal tenderness as a sign of peritoneal inflammation; * any clinical suspicion for diseases other than urolithiasis like abdominal aortic aneurysm or dissection; * patients with a history of drug addiction or known allergy to opioids; * patients who had used analgesics 6 hours before arriving.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in pain score | 20 and 40 minutes | change in pain severity based on Numerical Rating Score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| treatment side effects | 40 minutes | experiencing any side effects by the patients as a result of treatment protocols. |
Countries
Iran
Outcome results
None listed