Psychosis NOS, Schizoaffective Disorder, Schizophrenia
Conditions
Keywords
Schizophrenia, Schizoaffective disorder, Psychosis, Early phase, Cognitive remediation, Functional outcome
Brief summary
The purpose of the study is to investigate the effect of a 30 hour cognitive remediation program for young patients with early phase schizophrenia spectrum disorders on cognitive, clinical and functional outcome measures. The remediation program is integrated with whatever active rehabilitation the participant is currently attending (school, work, day program etc).
Interventions
BEHAVIORALCognitive remediation
Cognitive remediation including feedback from neurocognitive assessment, psychoeducation about cognitive deficits, 30 hours of computer based drill and practise and strategy coaching based cognitive remediation, 1-3 collaborative meetings with cognitive specialist, participant, therapist and teacher, occupational therapist or other therapist (depending on participants rehabilitation situation) to enhance transfer of skills to daily functioning
Sponsors
Stiftelsen Helse og Rehabilitering
South-Eastern Norway Regional Health Authority
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Early phase schizophrenia, schizoaffective disorder, psychosis NOS * Less than 5 years since start of adequate treatment for psychotic disorder * Age between 18-40 * Norwegian speaking (sufficiently to understand and complete assessments)
Exclusion criteria
* Traumatic brain injury * Neurological disorder as determined by medical history * IQ below 70
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Social Functioning Scale (SFS) | Change in SFS scores from baseline to 4 months and 9 months | — |
| MATRICS Consensus Cognitive Battery (MCCB) | Change in MCCB performance from baseline to 4 months and 9 months | Included in the MCCB are measures of the following cognitive domains: Speed of Processing, Attention, Working memory, Verbal learning, Visual Learning, Reasoning and problem solving and Social Cognition. In addition the following tests are included: HVLT-R and BVMT-R delayed recall to measure memory, TMTB (Halstead Reitan) and Color Word Inteference Test (D-KEFS) to measure executive functioning), Digit span (WAIS-III)to measure working memory, Grooved Pegboard (Halstead Reitan) to measure motor function. |
| UCSD Performance Based Skilled Assessment Brief Version (UPSA-B) | Change in UPSA-B performance from baseline to 4 months and 9 months | — |
| Cognitive Assessment Interview (CAI) | Change in CAI scores from baseline to 4 months and 9 months | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Calgary Depression Scale | Change in CDS scores from baseline to 4 months and 9 months | — |
| Global Assessment of Function (GAF)- split version | Change in GAF scores from baseline to 4 months and 9 months | — |
| event related fMRI | Change in BOLD fMRI signal from baseline to 4 months | Event-related fMRI will be performed to measure neuronal activity during a spatial working memory tasks and an executive planning task. All fMRI data will be collected on Ullevål's 3 T General Electric Sigma HDx scanner. |
| Rosenberg Self-Esteem Scale (RSES) | Change in RSES scores from baseline to 4 months and 9 months | — |
Countries
Norway
Contacts
Primary ContactTorill Ueland, PhD
Backup ContactIngrid Melle, PhD
Outcome results
None listed