Kidney Cancer
Conditions
Keywords
rhabdoid tumor of the kidney
Brief summary
RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer. PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.
Detailed description
OBJECTIVES: * To investigate the expression and function of transposons in 50 primary rhabdoid tumors. OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.
Interventions
GENETICDNA analysis
GENETICfluorescence in situ hybridization
GENETICgene expression analysis
GENETICgene mapping
GENETICmicroarray analysis
GENETICpolymerase chain reaction
GENETICprotein expression analysis
OTHERlaboratory biomarker analysis
OTHERmedical chart review
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 1 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age * Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression and function of transposons in rhabdoid tumors | — |
Outcome results
None listed