Office Hysteroscopy and Endometrial Snip Improve Intrauterine Insemination Outcome

Does Office Hysteroscopy and Endometrial Snip Improve IUI Outcome? : a Randomized Controlled Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01544426

Enrollment

332

Registered

2012-03-06

Start date

2012-02-29

Completion date

2014-10-31

Last updated

2014-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Office hysteroscopy,, intrauterine insemination, endometrial scrap

Brief summary

Endometrial injury had been studied before prior to intracytoplasmic sperm injection (ICSI) cycles , in cases of repeated implantation failure. It is found that it will improve the implantation rate.

Detailed description

The investigators can combine office hysteroscopy to diagnose hidden endometrial pathology, with hysteroscopically guided endometrial snip from the fundus of the uterus, trying to improve the pregnancy rate.

Interventions

PROCEDUREOffice hysteroscopy and endometrial snip

Office hysteroscopy with endometrial snip

PROCEDUREOffice hysteroscopy

Office hysteroscopy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 38 Years

Healthy volunteers

Inclusion criteria

* 18- 38 years old * at least one patent tube * unexplained infertility, anovulation, mild to moderate male factor infertility * previous failed IUI

Exclusion criteria

* indicated for ICSI

Design outcomes

Primary

Measure	Time frame	Description
Clinical pregnancy rate	10 month	Positive pregnancy test with fetal heart activity

Secondary

Measure	Time frame	Description
Ongoing pregnancy rate	12 month	Pregnancy Continued after 12weeks

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026