Healthy Volunteers (Middle-aged Smokers)
Conditions
Keywords
Polyphenol, Curcumin, Endothelium, vascular, Endothelium-dependant relaxing factor, Smoking, Transcriptome
Brief summary
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
Detailed description
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
Interventions
DRUGCurcumin
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
Sponsors
University Hospital, Clermont-Ferrand
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Association Régionale de Cardiologie d'Auvergne
ARDEC Association de Recherche de Développement et d'Enseignement de la Cardiologie
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 50 to 70 year-old volunteers * smokers
Exclusion criteria
* treated hypertension * treated hypercholesterolemia * chronic disease * vegetarian or other unusual diets * chronic alcoholism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in brachial Flow Mediated Dilatation | at Visit 1 (Day 0) and visit 2 (Day3/day5) |
Secondary
| Measure | Time frame |
|---|---|
| Changes in fingertip arterial tonometry | at visit 1 (day 0) and visit 2 (day3/day5) |
| Modifications of leukocytes transcriptome | at visit 1 (day 0) and visit 2 (day3/day 5) |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORJean-René LUSSON
University Hospital, Clermont-Ferrand
Outcome results
None listed