Studying Biomarkers in Samples From Younger Patients With Wilms Tumor

Biological Analysis of Ethnic Variations in Wilms Tumor

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01542333

Enrollment

Registered

2012-03-02

Start date

2012-02-29

Completion date

Unknown

Last updated

2016-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Cancer

Keywords

recurrent Wilms tumor and other childhood kidney tumors, stage I Wilms tumor, stage II Wilms tumor, stage III Wilms tumor, stage IV Wilms tumor, stage V Wilms tumor

Brief summary

RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.

Detailed description

OBJECTIVES: * To determine a unique molecular finger print of primary Wilms tumor arising in ethnically diverse children who are at increased risk to develop this lethal malignancy and subsequently relapse. * To determine a unique protein finger print from the urine of ethnically diverse children who develop Wilms tumor and subsequent relapse. OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine samples collected at the time of diagnosis and before treatment, are analyzed for molecular and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.

Interventions

GENETICgene expression analysis

GENETICproteomic profiling

GENETICreverse transcriptase-polymerase chain reaction

GENETICwestern blotting

OTHERimmunohistochemistry staining method

OTHERlaboratory biomarker analysis

PROCEDUREspectroscopy

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Diagnosed with Wilms tumor * Specimens from African-American and from Caucasian children * Specimens from each ethnicity who relapsed * Specimens from each ethnicity who did NOT relapse PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Molecular finger print of primary Wilms tumor in ethnically diverse children	—
Protein finger print from the urine of ethnically diverse children	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026