Hemodynamic Responses During Tracheal Intubation
Conditions
Brief summary
The purpose of this study is to evaluate the effect site concentration of remifentanil blunting hemodynamic changes to tracheal intubation of single or double lumen tubes.
Interventions
DRUGRemifentanil
According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during double lumen tube intubation. For this allocation of dose of remifentanil the investigators use up-and-down method. For the first patient, the dose of remifentanil would be fixed at 6.0 ng/ml which we predict as EC50. And, step size of dose is 0.5ng/ml.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing thoracic surgery that require one lung ventilation
Exclusion criteria
* patient who does not agree with this study * BMI \< 16.0 or BMI \> 30 * cardiovascular disease, pulmonary disease, renal disease * alcoholic abuser or drug abuser * patient who takes any drug to influence cardiovascular system or sympathetic nervous system * any use of local anesthetics or drugs to influence cardiovascular system during tracheal intubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes from baseline in heart rate and mean arterial pressure after intubation | intubation period | Heart rate and mean arterial pressure will be recorded at 2 minutes before intubation, 1 minute before intubation, during intubation, 1 minute after intubation. The mean value of heart rate and mean arterial pressure before intubation will be regarded as the baseline values. If maximum heart rate or mean arterial pressure after intubation increased by \>15% from baseline value, the response will be regarded as fail and increased concentration of remifentanil will be applied to next patient by up and down sequential method. |
Countries
South Korea
Outcome results
None listed