Comparison of Three Different No-contact Pachymetries

Phase 4 Study of Comparison Among 3 Different No-contact Instruments to Valuate Central Corneal Thickness

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01541501

Enrollment

150

Registered

2012-03-01

Start date

2011-09-30

Completion date

2012-12-31

Last updated

2012-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Thickness

Keywords

Central Corneal Thickness, Pachymetry

Brief summary

Study wants to compare central corneal thickness (CCT) obtained through 3 different no-contact instruments and to compare them with contact ultrasound pachymetry, actually the gold standard technique.

Detailed description

Corneal pachymetry is the measurement of corneal thickness, usually expressed in microns (μ). Pachymetry is systematically used for the monitoring of corneal oedema, for the management and assessment of the progression risk of the ocular hypertension, for the diagnosis, the management and follow-up of keratoconus, as well as it is important in the pre and postoperative management of corneal surgical procedures. CCT is a factor well known to influence tonometry. Its assessment is fundamental in glaucoma practice to allow a correct intraocular pressure (IOP) evaluation. The purpose of this study is to compare CCT measurements using four different instruments: Scheimpflug camera tomography, spectral-domain optical coherence tomography (SD-OCT), anterior chamber SD-OCT and ultrasound pachymetry.

Interventions

DEVICEPachymetry

Healthy volunteers recruited among subject that underwent a routine ophthalmologic evaluation or among both students and workers at our clinic, will be submitted to CCT measurement through four different instruments: Scheimpflug camera tomography, SD-OCT, anterior chamber SD-OCT, and finally with US pachymeter.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* subjects that gave a valid consensus to be included in this experimentation, * aged between 18 and 75 years, * Best-Corrected Visual Acuity (BCVA) of 20/100 or better, * refraction included between -6 and +6 dioptres, * astigmatism included between -2 and +2 dioptres.

Exclusion criteria

* History of refractive surgery or any keratoplasty procedure, * corneal opacities or diseases that make not suitable applanation tonometry or pachymetry. * Use of contact lenses. * History of corneal dystrophies or degenerative diseases, (like keratoconus and pellucid marginal degeneration). * History of glaucoma or ocular hypertension.

Design outcomes

Primary

Measure	Time frame	Description
Central Corneal Thickness (CCT) expressed in microns (μm)	partecipants will be followed for one day, i. e. until the CCT measurements with all instruments object of present study are taken	to valuate differences among all obtained no-contact CCT measurements and compare them with the CCT measured with the reference tool (Ultrasound pachymeter).

Secondary

Measure	Time frame	Description
Central Corneal Thickness (CCT) expressed in microns (μm)	partecipants will be followed for one day, i. e. until the CCT measurements with all instruments object of present study are taken	to valuate test-retest reliability of each instrument

Countries

Italy

Contacts

Primary ContactLuigi Varano, M. D.

luigi-varano@libero.it+39 0961 3647365

Backup ContactGiovanni Scorcia, M. D.

scorcia@unicz.it+39 0961 3647135

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026