Obsessive Compulsive Disorder
Conditions
Keywords
Obsessive Compulsive Disorder, Transcranial Magnetic Stimulation, Treatment
Brief summary
This study aimed at verifying whether sessions of repetitive transcranial magnetic stimulation over a certain brain area (the supplementary motor area) could be useful in the relief of Obsessive-Compulsive Disorder symptoms.
Detailed description
Patients were randomly administered either real (n = 12) or sham (n = 10) rTMS, once a day, 5 days a week, for 2 weeks. Randomization was performed according to a computer-generated schedule. Subjects and scale-rater physician were blind to treatment status of individuals. Only the rTMS administrator was aware of group allocations. Treatment response was assessed by self-and clinician-rated scales before treatment, immediately after treatment and 3 months thereafter, with the same examiner following a subject throughout the study. All patients included in the study had failed adequate pharmacological treatment for at least 2 antiobsessional drugs. Their prescription drugs were continued without change in dosage regimens throughout the study.
Interventions
DEVICERepetitive Transcranial Magnetic Stimulation (rTMS)
rTMS was administered by means of a NEURO-MS (NEUROSOFT LTD®, Russia) with a focal 8-shaped 70 mm coil. Stimulation parameters were 1-Hz, 20-min trains (1200 pulses/day) at 100% of resting MT, once a day, 5 days a week, for 2 weeks.
DEVICESham repetitive transcranial magnetic stimulation
The sham treatment was performed using the Neurosoft ® sham coil. A metal plate placed inside this coil prevents the magnetic field from stimulating the cortex. This coil looks and sounds like an active coil.
Sponsors
University of Brasilia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18 to 60 years * diagnosis of obsessive-compulsive disorder (OCD) according to DSM-IV-TR criteria and having OCD of at least moderate severity (YBOCS score of 16 or above).
Exclusion criteria
* subjects with comorbid psychiatric disorders (except depression - HAM-D ) or history of drug abuse * significant head injury, or of any neurosurgical procedure * pregnant women * patients with metal implants or illnesses that prevent attendance to sessions * patients with a history of seizure or bearing pacemakers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Y-BOCS scale scores relative to baseline | assessments were at baseline, at 2 weeks and at 3 months | Y-BOCS: Yale-Brown Obsessive-Compulsive Scale |
Countries
Brazil
Outcome results
None listed