Cerebral Blood Flow
Conditions
Brief summary
Berry fruits are widely recognised as natural functional food products. They contain several different phytochemicals which have potential to modulate human health and wellbeing. There is however some debate regarding the mechanisms driving their health promoting properties. Despite the wide health promoting properties of fruit extracts reported in the literature, considerable interest over the past decade has primarily been focused on their roles in reducing risk factors associated with cancer and heart disease. Consequently, there remains a paucity of actual scientific information on their role in modulating brain functions, such as mood, learning and memory, any decrements of which have very negative impacts on the quality of life. Fruit phytochemicals from other sources have been shown to mediate both peripheral and cerebral blood flow. However, a modulation of cerebral blood flow has not been shown with berries as yet. Cerebral blood flow must be maintained to ensure a constant delivery of oxygen and glucose as well as the removal of waste products. The modulation of cerebral blood flow via supplementation of berry polyphenols could therefore be a potential way to positively modulate human cognitive behavior. The link between acute increases in cerebral blood flow and increased cognition is currently a little weak but it could give a good platform for long term behavioral and health benefits via increased cerebral/peripheral blood flow and decreased MAO-B activity. The aims of the study are therefore to investigate the impact of the berry extract on digital volume pulse, blood pressure and cerebral blood flow.
Interventions
DIETARY_SUPPLEMENTControl
Sugar matched control containing berry flavouring and no phytochemicals
DIETARY_SUPPLEMENTBerry drink
Cold pressed berry drink standardised to contain 500mg of berry polyphenols
Sponsors
The New Zealand Institute of Plant and Food Research Ltd.
Northumbria University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * none smokers * aged between 18 and 35 years
Exclusion criteria
* History of neurological, vascular or psychiatric illness. * Current diagnosis of depression and/or anxiety. * History or current diagnosis of drug/alcohol abuse. * Anaemia. * Any heart disorder. * Hypertension * Any respiratory disorder. * Diabetes. * Food intolerances/sensitivities. * Phenylketonuria. * Use tobacco products or have ceased in the last 6 months. * Currently taking any prescribed, illicit or herbal drugs. * Any known active infections. * HIV antibody positive. * Currently have, have ever had, or may be at risk of hepatitis. * Have suffered from jaundice within the last year. * Have haemophilia or any similar clotting disorder. * History of head trauma * History of migraines * History of learning difficulties * Any Issues with giving blood samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Digital Volume Pulse | Change from baseline at 15, 30, 45, 60, 100, 120, 150, 180, 240 minutes and 24 hours post dose |
| Cerebral blood flow | Continuous measure from baseline to 100 minutes post dose |
| Blood platelet MAO-B activity | Change from baseline at 15, 30, 45, 60, 100, 120, 150, 180, 240 minutes and 24 hours post dose |
Countries
United Kingdom
Outcome results
None listed