Sublingual Misoprostol Versus Standard Surgical Care for the Treatment of Incomplete Abortion in Nigeria

Sublingual Misoprostol Versus Standard Surgical Care for the Treatment of Incomplete Abortion

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01539408

Enrollment

Registered

2012-02-27

Start date

2009-08-31

Completion date

2010-10-31

Last updated

2012-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Incomplete Abortion

Brief summary

Women diagnosed with incomplete abortion in this health facility will be randomized to receive one of the following regimens: 400 mcg sublingual misoprostol in one dose or standard surgical treatment (MVA). The investigators hypothesize that treatment of incomplete abortion with misoprostol using 400 mcg administered sublingually will be as effective as surgical evacuation.

Interventions

DRUGMisoprostol

single dose of 400 mcg misoprostol administered sublingually

PROCEDUREsurgery Manual vacuum aspiration (MVA)

standard surgical treatment

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* no contraindications to misoprostol * uterine size was not larger than 12 weeks * there were no signs of severe infection * haemodynamically stable * in general good health * willing to provide contact information

Exclusion criteria

* an IUD in place * ectopic pregnancy * aged below 18 years and had no accompanying adult to provide informed consent

Design outcomes

Primary

Measure	Time frame
Complete abortion without recourse to surgical intervention	follow up visit 7 days after initial treatment

Countries

Nigeria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026