Knee Osteoarthritis
Conditions
Keywords
Strength training, Biomechanics, Quadriceps, Gait
Brief summary
This is a longitudinal, randomized, controlled interventional multi centric study on the effects of lower leg strengthening exercise on quadriceps force during walking in people with knee osteoarthritis. At each study centre twenty subjects will be included, for a total of 40 participants. Subjects will be randomized equally (1:1) into 1 active arm and 1 control arm. The objective of the study is to evaluate the effect of twelve weeks of quadriceps strengthening on the mechanical output of the quadriceps during locomotion. A secondary purpose is to explore the relationship between quadriceps strengthening and compressive knee loadings. The hypothesis is that quadriceps strength training will not change quadriceps force, power, and work in locomotion in people with knee osteoarthritis. Primary outcome is quadriceps force during walking, secondary outputs are quadriceps power and work and knee compressive loads during walking. Explorative measures are isometric and concentric isokinetic leg muscle strength, radiographic score of the knee (Kellgren and Lawrence), a one-leg rise from chair test (maximum number of reps) and a lateral step-up test (maximum number of reps).
Interventions
OTHERStrength Training
The exercises will be performed in standard strength training equipment. Prior to each of the strengthening exercise sessions, a warm up phase is performed by 5-10 minutes of ergometer cycling at a moderate intensity. Muscle strengthening exercises will be performed according to the standard progressive resistance and overload principle. The exercise programme consists of three exercises performed with three sets of 10 repetitions at 60%-85% of patient's 10RM. Training load will be progressed by means of bi-weekly estimates of muscle strength to ensure a constant load of 60%-85% RM. Exercises are: 1. Leg extension, 2. Leg press, and 3. Forward lunges.
Sponsors
East Carolina University
Frederiksberg University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
A medical doctor will perform the screening of potential participants. Subjects must meet the following inclusion criteria to be eligible for study entry: * Knee OA diagnosed according to the American College of Rheumatology criteria (26), with clinical symptoms and radiographically verified tibio-femoral osteoarthritis in one or both knees. * Aged between 40 and 65 yrs. * Untrained (i.e. less than 2 hours of exercise per week) * Subject must not be using assistive walking device * Willing and able to complete study visits and procedures * Willing to hold activity and exercise level generally consistent during the study except that encompassed in the study. * In general good health, in the opinion of the investigator, based on medical history and physical examination and, if necessary, laboratory values. Laboratory tests are prescribed by the medical doctor at the screening visit. * A body mass index (BMI) of 19\<BMI≤32kg/m2 * Speaks, reads and writes Danish and/or English language
Exclusion criteria
Subjects who meet any of the following
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in peak quadriceps force during walking at 12 weeks | Baseline and at 12 weeks | Estimates of the quadriceps muscle forces during locomotion are calculated using a biomechanical model based on data from gait analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in quadriceps power and work during walking at 12 weeks | Baseline and after 12 weeks | Estimated from gait analysis |
| Change from baseline in knee compressive force during walking at 12 weeks | Baseline and after 12 weeks | Estimated from biomechanical modelling of data from gait analysis |
Countries
Denmark, United States
Outcome results
None listed