Surgical Side Infections After Breast Reduction
Conditions
Keywords
surgical side infection, breast reduction, reduction mammaplasty, prospective trial, microcirculation, breast surgery
Brief summary
In this prospective study we investigated the impact of an improved postoperative microcirculation and its effect of surgical side infections after breast reduction.
Detailed description
Many studies identifying risk factors for surgical side infections (SSI) after breast surgery included a large percentage of breast conserving therapies and risk factors for patients undergoing more extensive procedures like breast reduction (BR) are underrepresented and risk factors for more extensive breast surgeries might not be identified. Our approach to decrease SSI after BR was the application of an i.v. isotonic crystalloid solution, 6% hydroxyethylstaerke (HES) as a diminished peripheral blood flow and impaired vasculogenesis are characteristics of poorly healing wounds. HES causes a medium- to long-term increase in blood volume, blood flow and improved blood oxygen transport. Blood flow and tissue oxygenation are parts of regulating the healing process by utilizing molecular oxygen as a terminal oxidant. This antioxidant capacity can influence the wound healing process positively, as a characteristic feature of the inflammatory phase is the oxidative burst. HES additionally decreases haematocrite, blood viscosity and aggregation of erythrocytes positively influencing the complex components regulating wound healing. These characteristics and the increase in blood circulation might influence the postoperative healing and regeneration process.
Interventions
DRUG250ml HES 6%
Application twice a day 250ml HES 6% for three days postoperatively.
DRUG9% NaCl 500ml
Application twice a day 500ml 9% NaCl for three days postoperatively.
Sponsors
University of Rostock
Max Dieterich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Eligible patients were at least 18 years of age, scheduled for breast reduction, guaranteed follow-up of 30 days.
Exclusion criteria
* Patients were excluded if they had a history of coagulopathy or history of antiplatelet agent use within 10 days of surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Surgical side infection | 4 weeks | Primary end point was the development of surgical side infection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors | 4 weeks | Secondary endpoints were identification of possible risk factors for surgical side infections and nipple necrosis after breast reduction. |
Countries
Germany
Outcome results
None listed