Antiphospholipid Syndrome, Severe Preeclampsia
Conditions
Keywords
Antibodies, anticardiolipin, Antibodies, B2 Glycoprotein I, Lupus Anticoagulant, Severe Preeclampsia
Brief summary
The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications (miscarriages, stillbirths). Since 1999 the Sapporo Criteria for Antiphospholipid Syndrome diagnosis includes the development of severe preeclampsia before 34 weeks of gestation, but this was done without solid evidence of a relation between the two. Our study will try to add information to this particular point.
Interventions
None listed
Sponsors
Saint Thomas Hospital, Panama
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Gestational age between 24-34 weeks * Diagnosis of severe preeclampsia
Exclusion criteria
* Known antiphospholipid syndrome. * Known presence of antiphospholipid antibodies. * Patients with systemic lupus erythematosus.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lupus anticoagulant | 15 months | Number of cases positive for Lupus Anticoagulant. |
| Anticardiolipin antibodies | 15 months | Number of cases with high/medium levels of IgG/IgM of anticardiolipin antibodies. |
| B2 Glycoprotein I | 15 months | Number of cases with levels of B2 Glycoprotein 1 \> 99% |
Countries
Panama
Outcome results
None listed