Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction

Changes in Muscle Morphology Resulting From ACL Reconstruction: Impact on Strength and Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01537588

Enrollment

Registered

2012-02-23

Start date

2009-07-31

Completion date

2012-07-31

Last updated

2015-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Isolated Anterior Cruciate Ligament Rupture

Keywords

anterior cruciate ligament, hamstring, semitendinosus, gracilis, graft

Brief summary

The aim of this study is to gain new knowledge on the impact of hamstring tendon harvest and apply that knowledge to the treatment and management of patients who undergo anterior cruciate ligament (ACL) reconstruction. There are three main components of this study: 1. How do muscle shape, size, strength, and ability to function change following hamstring grafting for ACL reconstruction; 2. How does physical activity change following ACL reconstruction; 3. Is there a difference in outcome if graft harvest is done from the injured versus uninjured limbs

Interventions

OTHERAutograft STG harvest from ACL-deficient leg

Semitendinosus-gracilis graft harvest is undertaken on same limb that is undergoing ACL reconstruction

OTHERAutograft harvest contralateral to ACL-deficient leg

Semitendinosus-gracilis graft harvest is undertaken on limb contralateral to that undergoing ACL reconstruction

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* between 18 and 50 years old; isolated ACL rupture confirmed on MRI

Exclusion criteria

* other physical or mental health issues that affect ability to complete rehabilitation and/or study follow-ups

Design outcomes

Primary

Measure	Time frame	Description
Muscle cross sectional area	12 months post-surgery	Measured on bilateral MRI taken from ischial tuberosity to 10 cm below knee joint line

Secondary

Measure	Time frame	Description
Knee flexion and extension isokinetic strength	12-months post-surgery	Eccentric anc concentric strength measured at 60, 150, and 270 degrees/second on dynamometer in sitting and in 5 degrees hip flexion
Physical activity	12 months post-surgery	7-day record of activity using accelerometer.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026