Diabetes, Pancreas Transplantation, Renal Failure
Conditions
Keywords
Diabetes Mellitus, Pancreas, Renal failure, Transplantation
Brief summary
The purpose of this study is to evaluate the beneficial effect of pancreas transplantation for long term kidney function in patients undergoing single-pancreas transplantation.
Detailed description
Renal failure in patients who have performed a pancreas transplantation is a hazard for the outcome for these patients. The beneficial effect of pancreas transplantation for renal function is not clear. It is of major importance to early find patients who develops a decrease in renal function and start treatment early and closely monitor these patients in order to avoid further deteriorating renal function. In order to achieve this, there is a need for a easy, fast and sensitive method to evaluate renal function. In this study the investigators plan to use the non-invasive MR to evaluate changes in renal function.
Interventions
None listed
Sponsors
Uppsala University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with diabetes mellitus * Patients undergoing a pancreas transplantation
Exclusion criteria
* Patients undergoing a pancreas transplantation and a renal transplantation at the same time.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Kidney function | Within 3 years | Improvements in kidney function (GFR) and proteinuria after pancreas transplantation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Kidney hemodynamics and oxygenation | Within 3 years | Improvements in renal blood flow and kidney tissue oxygenation after pancreas transplantation. |
Countries
Sweden
Outcome results
None listed