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Attachment Based Family Therapy for Suicidal Adolescents

Attachment Based Family Therapy (ABFT) for Suicidal Adolescents

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01537419
Enrollment
129
Registered
2012-02-23
Start date
2012-03-31
Completion date
2016-12-31
Last updated
2018-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Family Relationships, Suicide

Keywords

Suicide, Depression, Family Relationships

Brief summary

This study will evaluate the efficacy of attachment based family therapy (ABFT) for treatment of suicidality in adolescents. The study will compare 16 weeks of treatment with ABFT to a control condition Family Enhanced Non-directive Supportive Therapy (FE-NST).

Detailed description

Suicide is the third leading cause of death for American adolescents. Nearly one million adolescents a year attempt suicide and about 500,000 adolescents a year are admitted to psychiatric hospitals for suicide attempts or serious suicidal ideation. This leads to high emotional costs for families and financial cost for the health system. Yet, no medication, and less than 10 psychotherapy studies have focused on suicidal youth and findings are mixed. There has been a call for new and innovative approaches for depression treatment highlights the need for alternative interventions for suicidal youth as well. Attachment-Based Family Therapy (ABFT) offers a promising alternative to prior treatments. It is a manualized family therapy targeting processes associated with suicide and depression. ABFT seeks to improve the adolescent-caregiver relationship by increasing the family's capacity for discussing and negotiating affectively charged issues in the relationship. Improvements in the attachment relationship provide adolescents with improved capacity for affect regulation and the ability to use the caregiver as a source of protection and support. These strengths buffer adolescents against suicide and other risk behaviors. Four studies have demonstrated that ABFT can reduce suicidal ideation and depressive symptoms with an average effect size of .97. Unfortunately, interpretation of these studies is compromised by lack of a controlled comparison treatment. This study aims to test the efficacy of ABFT using a comparison group that controls for treatment dose, duration, therapist expertise, ecological factors, and family involvement. The study includes one year follow-up data, assessment staff blind to treatment condition and tests of the purported active ingredients of ABFT. Putative change processes will be tested including: a)adolescents' expectancies for parent availability, b) emotion regulation during parent-adolescent conflict discussions, and c) resolution of loss and abuse. To test this, Dr. Kobak, a leading adolescent attachment researcher, will use the Adult Attachment Interview and observational coding of the family interaction task to test these treatment mechanisms. If successful, the findings will provide evidence for both the efficacy and specificity of a family based treatment mechanism. The investigators will recruit and randomize 130 adolescents to 16 weeks of ABFT or Family-Enhanced Non-directive Supportive Therapy (FE-NST). Assessments will be conducted at baseline, 8, 16, 32 and 52 weeks. The primary and secondary aims assess whether ABFT reduces suicidal ideation, depression, family conflict, and future suicide attempts more effectively than control. Exploratory aims test a) whether ABFT can improve parent adolescent attachment, b) if attachment mediates outcome, and if a history of trauma, parental depression or family conflict moderate outcome. The study targets adolescents with severe and persistent suicidal ideation selected from inner city, minority youth.

Interventions

Although ABFT therapists implement behavior focused and psychoeducational interventions, the model is primarily a process oriented, emotion focused treatment guided by a semi-structured treatment protocol. ABFT aims to improve the family's capacity for problem solving, affect regulation, and organization. This strengthens family cohesion which can buffer against depression, suicidal thinking, and risk behaviors.

BEHAVIORALFamily-Enhanced Non-directive Supportive Therapy

Family-Enhanced Non-directive Supportive Therapy (FE-NST) is a 16 week therapy designed to control for the non-specific effects of psychotherapy with suicidal youth. FE-NST aims toward relief or reduction of symptoms without expectation of change in the basic personality structure. We have added a parent component to: a) control for parent involvement and b) improve the generalizability and safety of the FE-NST treatment. This enhancement consists of 5 potential parent sessions beginning with a family safety plan in the initial treatment session that will be monitored regularly throughout the treatment. The remaining 4 parent psycho-education sessions offer parents knowledge, skills and support to improve management of the suicidal teen.

Sponsors

National Institute of Mental Health (NIMH)
CollaboratorNIH
Drexel University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
12 Years to 18 Years
Healthy volunteers
No

Inclusion criteria

* Adolescents between the ages of 12 and 18 * Adolescents endorse severe suicidal ideation (SIQ-JR \> 31) and moderate depression (BDI-II \> 20) at two time points (1 to 3 days) * At least one primary parent or caregiver must participate in the assessment and treatment. This could be a biological parent, stepparent, grandparent, other relative, or a foster parent, who has at least frequent contact with the subject. When possible both parents will participate in the assessment and treatment. Legal custody is always considered (e.g., divorced parents). Having all family members present at every session is not required. Many individual meetings with the subject or the parent are planned in both treatments.

Exclusion criteria

* Evidence of imminent risk of harm to self or others that cannot be safely treated on an outpatient basis * Evidence of psychotic features \[as reported on the Diagnostic Interview Schedule for Children; Voice Diagnostic Interview Schedule for Children (VDISC)\] * Evidence of suffering from severe cognitive impairment (e.g., mental retardation, severe developmental disorders) as evidenced by educational records, parental report and/or clinical impression). * Subjects taking antidepressant medication for depression for less than 6 weeks prior to the screening.

Design outcomes

Primary

MeasureTime frameDescription
Change in the Intensity of Suicidal Ideation Between Intake and End of Treatment16 weeks (end of treatment)The Suicidal Ideation Questionnaire-JR is a 15-item self-report assessment. It is based on Reynolds' theoretical notion of suicidality forming a continuum ranging from thoughts of death, thoughts of wanting to be dead, general and specific suicidal plans, preparations for carrying out plans, and actual suicide attempts. The scale ranges from 0 to 90, with a score of 0 being representative of no suicidal ideation, and a score of 31 or greater indicating severe suicidal ideation.
Change in the Severity of Depression Symptoms Between Intake and End of Treatment16 weeks (end of treatment)Beck Depression Inventory-II. The second edition of the BDI is a widely-used, 21-item self-report instrument designed to assess the severity of depressive symptoms in adults and adolescents. The BDI-II has 21 items and takes approximately 5 minutes to complete. The scale ranges from 0 to 63, with a higher score being representative of a greater clinical magnitude of depression: a total score of 0-13 is considered minimal depression, 14-19 is mild depression, 20-28 is moderate depression, and 29-63 is severe depression.

Secondary

MeasureTime frameDescription
Change in the Evidence of Family Conflict Between Parent and Youth After Intervention Between Intake and End of Treatment16 weeks (end of treatment)The Self-Report of Family Functioning consists of 10 items selected from a number of well-known family assessment measures (Family Environment Scale, Family Concept Q-Sort, Family Adaptability and Cohesion Scale, and Family Assessment Measure). The scale ranges from 10 to 40, with a score of 10 being representative of no family conflict and a score of 40 being representative of the greatest magnitude of family conflict. Therefore, a decrease in score represents and decrease in self-reported family conflict.

Countries

United States

Participant flow

Participants by arm

ArmCount
Family-Enhanced Non-directive Supportive Therapy
Family-Enhanced Non-directive Supportive Therapy (FE-NST) is a 16 week therapy designed to control for the non-specific effects of psychotherapy with suicidal youth. FE-NST aims toward relief or reduction of symptoms without expectation of change in the basic personality structure. We have added a parent component to: a) control for parent involvement and b) improve the generalizability and safety of the FE-NST treatment. This enhancement consists of 5 potential parent sessions beginning with a family safety plan in the initial treatment session that will be monitored regularly throughout the treatment. The remaining 4 parent psycho-education sessions offer parents knowledge, skills and support to improve management of the suicidal teen.
63
Attachment-Based Family Therapy
Although ABFT therapists implement behavior focused and psychoeducational interventions, the model is primarily a process oriented, emotion focused treatment guided by a semi-structured treatment protocol. ABFT aims to improve the family's capacity for problem solving, affect regulation, and organization. This strengthens family cohesion which can buffer against depression, suicidal thinking, and risk behaviors. Attachment-Based Family Therapy: Although ABFT therapists implement behavior focused and psychoeducational interventions, the model is primarily a process oriented, emotion focused treatment guided by a semi-structured treatment protocol. ABFT aims to improve the family's capacity for problem solving, affect regulation, and organization. This strengthens family cohesion which can buffer against depression, suicidal thinking, and risk behaviors.
66
Total129

Baseline characteristics

CharacteristicFamily-Enhanced Non-directive Supportive TherapyAttachment-Based Family TherapyTotal
Age, Customized
<=15 Years Old
40 Participants36 Participants76 Participants
Age, Customized
>15 Years Old
23 Participants30 Participants53 Participants
Ethnicity (NIH/OMB)
Hispanic or Latino
9 Participants11 Participants20 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
54 Participants55 Participants109 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants
Race (NIH/OMB)
American Indian or Alaska Native
2 Participants0 Participants2 Participants
Race (NIH/OMB)
Asian
1 Participants2 Participants3 Participants
Race (NIH/OMB)
Black or African American
33 Participants31 Participants64 Participants
Race (NIH/OMB)
More than one race
4 Participants6 Participants10 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
1 Participants0 Participants1 Participants
Race (NIH/OMB)
Unknown or Not Reported
6 Participants6 Participants12 Participants
Race (NIH/OMB)
White
16 Participants21 Participants37 Participants
Sex: Female, Male
Female
52 Participants55 Participants107 Participants
Sex: Female, Male
Male
11 Participants11 Participants22 Participants
Sexual Orientation
Bisexual
9 Participants13 Participants22 Participants
Sexual Orientation
Heterosexual
50 Participants38 Participants88 Participants
Sexual Orientation
Lesbian/Gay
2 Participants8 Participants10 Participants
Sexual Orientation
Questioning
2 Participants7 Participants9 Participants
Socioeconomic Status
Above Poverty Level
44 Participants45 Participants89 Participants
Socioeconomic Status
Below Poverty Level
19 Participants21 Participants40 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 630 / 66
other
Total, other adverse events
27 / 6327 / 66
serious
Total, serious adverse events
0 / 630 / 66

Outcome results

Primary

Change in the Intensity of Suicidal Ideation Between Intake and End of Treatment

The Suicidal Ideation Questionnaire-JR is a 15-item self-report assessment. It is based on Reynolds' theoretical notion of suicidality forming a continuum ranging from thoughts of death, thoughts of wanting to be dead, general and specific suicidal plans, preparations for carrying out plans, and actual suicide attempts. The scale ranges from 0 to 90, with a score of 0 being representative of no suicidal ideation, and a score of 31 or greater indicating severe suicidal ideation.

Time frame: 16 weeks (end of treatment)

ArmMeasureValue (MEAN)Dispersion
Family-Enhanced Non-directive Supportive TherapyChange in the Intensity of Suicidal Ideation Between Intake and End of Treatment-27.42 units on a scaleStandard Deviation 2.52
Attachment-Based Family TherapyChange in the Intensity of Suicidal Ideation Between Intake and End of Treatment-31.55 units on a scaleStandard Deviation 2.5
Primary

Change in the Severity of Depression Symptoms Between Intake and End of Treatment

Beck Depression Inventory-II. The second edition of the BDI is a widely-used, 21-item self-report instrument designed to assess the severity of depressive symptoms in adults and adolescents. The BDI-II has 21 items and takes approximately 5 minutes to complete. The scale ranges from 0 to 63, with a higher score being representative of a greater clinical magnitude of depression: a total score of 0-13 is considered minimal depression, 14-19 is mild depression, 20-28 is moderate depression, and 29-63 is severe depression.

Time frame: 16 weeks (end of treatment)

ArmMeasureValue (MEAN)Dispersion
Family-Enhanced Non-directive Supportive TherapyChange in the Severity of Depression Symptoms Between Intake and End of Treatment-4.87 units on a scaleStandard Deviation 0.5
Attachment-Based Family TherapyChange in the Severity of Depression Symptoms Between Intake and End of Treatment-5.40 units on a scaleStandard Deviation 0.5
Secondary

Change in the Evidence of Family Conflict Between Parent and Youth After Intervention Between Intake and End of Treatment

The Self-Report of Family Functioning consists of 10 items selected from a number of well-known family assessment measures (Family Environment Scale, Family Concept Q-Sort, Family Adaptability and Cohesion Scale, and Family Assessment Measure). The scale ranges from 10 to 40, with a score of 10 being representative of no family conflict and a score of 40 being representative of the greatest magnitude of family conflict. Therefore, a decrease in score represents and decrease in self-reported family conflict.

Time frame: 16 weeks (end of treatment)

ArmMeasureValue (MEAN)Dispersion
Family-Enhanced Non-directive Supportive TherapyChange in the Evidence of Family Conflict Between Parent and Youth After Intervention Between Intake and End of Treatment-1.058 units on a scaleStandard Deviation 2.95232
Attachment-Based Family TherapyChange in the Evidence of Family Conflict Between Parent and Youth After Intervention Between Intake and End of Treatment-1.2538 units on a scaleStandard Deviation 2.71817

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026