Parkinson
Conditions
Keywords
Electrophysiology, Subthalamic nucleus, Parkinson
Brief summary
The role of the basal ganglia in the processing of information with emotional or motivational content has been demonstrated by several lesion and functional imaging studies in humans and animals. Deep brain stimulation surgery provides an opportunity to study these structures in humans in electrophysiological terms. The aim of this study is to investigate modifications in the electrophysiological activity of the subthalamic nucleus (STN) during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson's disease who have just undergone implantation of a deep brain stimulator in the STN.
Interventions
OTHERMeasure of the electrophysiological activity of the subthalamic nucleus
Local field recording of the subthalamic nucleus by mean of externalized electrodes in the immediate postoperative periode.
Sponsors
Rennes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with Parkinson's disease selected for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in accordance with the criteria established by Welter and colleagues (Welter et al., 2002); * Aged 18 years or above; * Written informed consent from the patient.
Exclusion criteria
* Patient under a legal incapacity or with limited legal capacity; * Patient who has perioperative complications or postoperative confusion; * Patient displaying cognitive disturbances involving the early stages of speech processing (on the basis of an audiogram systematically conducted prior to surgery) ; * Patient displaying cognitive disturbances involving the early stages of face processing (on the basis of the Benton Facial Recognition Test (Benton, Hamsher, Varney, \& Spreen, 1983) systematically administered prior to surgery); * Patient incapable of understanding the information given about the study, performing the tasks or providing informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electrophysiological activity of the subthalamic nucleus | 5 days | Electrophysiological activity of the subthalamic nucleus will be measured during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson disease who have just undergone implatation of a deep brain stimulator in the subthalamic nucleus |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMarc Verin, MD, PhD
Rennes University Hospital
Outcome results
None listed