Type 2 Diabetes Mellitus
Conditions
Keywords
Diabetes mellitus, accelerated aging, cellular senescence, diabetic cardiomyopathy, strain imaging, strain rate imaging,, echocardiography
Brief summary
The potential clinical implications of this study are to optimise the selection of a population at risk for developing a diabetic cardiomyopathy among diabetic patients in order to develop early therapeutic strategies to prevent the left ventricular remodelling. Therefore, the originality of this project is to hypothesize that : * Diabetes mellitus is often associated with a premature aging syndrome * Cellular senescence may potentiate the mechanisms that are involved in decreasing myocardial contractility in DM and, * DM associated to premature aging may increase the risk of developing a cardiomyopathy Thus, the modulation of telomerase activity and the control of telomere length, together with the attenuation of the formation of reactive oxygen species, might represent important new targets in order to develop therapeutic tools in prevention of diabetic cardiomyopathy.
Interventions
OTHERCardiac RMI
Cardiac RMI
OTHERAnalysis telomere
Analysis telomere
OTHERStress test
Stress test
OTHERechocardiography
echocardiography
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 Diabetes mellitus * 40 \< Age \< 55 years old * oral antidiabetic or insulin treatment * No symptoms * Sinus rhythm * no sign or history of heart disease * LVEF \> 55% * Absence of regional left ventricular motion abnormalities.
Exclusion criteria
* absence of sinus rhythm, * silent ischemia defined as positive exercise test or positive stress echocardiography, * history of cardiomyopathy or CAD, * valvular heart disease hemodynamically significant, * severe renal insufficiency defined as creatinine clearance \< 30 mL/min, * echocardiographic images unsuitable for quantification, * type 1 diabetes mellitus, * Important diabetes mellitus imbalance defined as glycated hemoglobin \> 9% or glycemia \> 3g/L uncontrolled hypertension (\> 180/100 mmHg).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Telomere shortening | 36 months | Investigate whether biomarkers for senescence determined from blood samples, including telomere shortening and telomerase activity in diabetic patients have an impact of left ventricular remodelling as compared with age-matched controls and biological aged control subjects. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dysfunction by speckle tracking imaging | 36 months | Study the incidence of subtle regional myocardial dysfunction by speckle tracking imaging (longitudinal and radial systolic strain) |
| Determine the predictive value of alteration | 36 months | Determine the predictive value of alteration : Proteinuria, glycosylated haemoglobin, diabetes mellitus duration, blood pressure, BNP dosage, MRI diagnoses |
| Cardiovascular events | 36 months | Investigate the predictive value of all those factors( telomere shortening, telomerase activity, echo abnormalities) on cardiovascular events including MI, HF, arrhythmia; ACV |
Countries
France
Outcome results
None listed