Inflammation
Conditions
Brief summary
There is a constant exchange between the gut epithelium and lumen, including microbial interplay. The aim of this study was to investigate dietary test products on inflammatory proliferation markers in the gut, and thereby if the products had positive effects in the gut as well as in other parts of the body. The hypothesis was that the test products would reduce the inflammatory and proliferation activity of the gut epithelium by fermentation of normal food products and by converting dietary phenolic compounds into anti-inflammatory substances.
Interventions
DIETARY_SUPPLEMENTLactobacillus
Intervention (2 weeks) with a strain of Lactobacillus
DIETARY_SUPPLEMENTBifidobacterium
Intervention (2 weeks) with a strain of Bifidobacterium
Sponsors
Region Skane
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-80 years old, * Able to understand oral and written information, * Informed consent
Exclusion criteria
* Ongoing immune suppressive treatment, incl. cortisone, * Ongoing antibiotic treatment or antibiotic treatment ended within 4 weeks, * History of inflammatory bowel disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reactivity of rectal mucosa | after 2 weeks intervention | to study the reactivity of rectal mucosa after a standardized inflammatory insult before and after treatment with probiotics |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| influence on immune system | after 2 weeks intervention | to study the influence on systemic leukocytes and regulatory T cells |
Outcome results
None listed