Inflammation, Sleep Problems
Conditions
Keywords
Sleep, inflammation, mindfulness, meditation, randomized controlled trial
Brief summary
The primary aim of the study is to test the effect of mindfulness training on sleep parameters among older adults with insomnia symptoms The secondary aims are to examine if changes in mindfulness meditation practice (daily log) and level of mindfulness (self-report) are associated with changes in sleep parameters, and to determine if mindfulness training is associated with in vitro biological markers of peripheral inflammation
Interventions
BEHAVIORALMindfulness Meditation
Participants will attend weekly 2-hour classes for a total of 6 weeks and participants will monitor their sleep with a daily sleep diary.
BEHAVIORALSleep Education
Participants will attend weekly 2-hour classes for a total of 6 weeks and participants will monitor their sleep with a daily sleep diary.
Sponsors
University of California, Los Angeles
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Men and women (all races and ethnicities) 55 years of age and older * Have current problems sleeping * Fluent in English * Able to understand and provide signed informed consent * Willing to be randomly assigned to treatment condition
Exclusion criteria
* Individuals currently undergoing major medical treatment such as surgery, radiation, or immunotherapy * Individuals living outside of a 20 mile radius from the UCLA Medical Center * Individuals with current substance dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep | Within 2 weeks post-intervention | Primary sleep outcomes to be assessed include Daily sleep diary, Pittsburgh Sleep Quality Index, Fatigue Symptom Inventory, Insomnia Severity Index, and Pre-Sleep Arousal Scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mindfulness | Within 2 weeks post-intervention | Mindfulness will be assessed by self report with the Five Facet Mindfulness Questionnaire and a daily log of amount of mindfulness practice |
| Inflammatory Biology | Within 2 weeks post-intervention | Pro-inflammatory cytokines and associated transcription markers will be assessed with in vitro assay of peripheral blood via venipuncture collected between 9am and 1130am |
Countries
United States
Outcome results
None listed