Head Injury Trauma Blunt
Conditions
Brief summary
The investigators are assessing the platelet function analysis of those who sustained significant head trauma while on aspirin or plavix and to assess if any qualitative difference is obtained if platelets are administered.
Detailed description
The platelet function analyzer VerifyNow® P2Y12 uses ADP as agonists to induce platelet activation and ascertain the level of platelet function impaired by these medications. VerifyNow® Aspirin Assay utilizes arachidonic acid as the agonist to measure platelet function specifically along this pathway. Our research question for this study is as follows: Does the administration of desmopressin (DDAVP) and/or the transfusion of platelets in patients with head trauma reverse the platelet inhibition caused by Aspirin and/or Plavix? The investigators hypothesize that with the administration of platelets and/or DDAVP that there is a reversal of the inhibition.
Sponsors
Santa Barbara Cottage Hospital
Accumetrics, Inc.
Chang, Steve S., M.D.
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age \> 18yrs 2. Must be a trauma patient with blunt head trauma. 3. Must be on Aspirin and/or Plavix 4. Subject or Legally Authorized Representative (LAR) (per Heath and Safety Code, Sections 24170 to 24179.5) must sign study consent within 4 hours from the first blood draw. (If this criterion is not met the initial blood draw must be destroyed and NOT run for study results).
Exclusion criteria
1. Hemoglobin ≤ 10 GM/DL 2. Platelet Count ≤ 150 K/MCL 3. Pregnant Females 4. Subjects on Warfarin, Heparin or Enoxaparin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet inhibition | 8 hours | We are measuring platelet inhibition using the verify now platelet function analyzer |
Countries
United States
Outcome results
None listed