Cardiovascular Diseases
Conditions
Keywords
Black tea, phenolic acids
Brief summary
This study is set up to determine pharmacokinetics of phenolic acids after a single oral dose to healthy males.
Interventions
DIETARY_SUPPLEMENThot water
Hot water and placebo capsule
DIETARY_SUPPLEMENTBlack tea and phenolic acids
Black tea extract and capsule with phenolic acids
Sponsors
Unilever R&D
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy males * not smoking
Exclusion criteria
* use of NSAIDS and/or antibiotics * no blood donation 1 months prior to screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentrations of selected phenolic acids | up to 30 hrs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| plasma concentration of selected flavonoid metabolites | up to 30 hrs | — |
| Identification of unknown phenolic acids (metabolites of black tea) in plasma | up to 30 hrs | It is still largely unknown which metabolites are formed in-vivo after black tea ingestions and circulating in human plasma. Untargeted profiling using LC-MS of plasma samples will be used to identify yet unknown polyphenols / phenolics and their conjugates in plasma and thus extent the hit-list of known metabolites in circulation after black tea consumption |
Countries
France
Outcome results
None listed