Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients

Effect of Epinephrine on Systemic Absorption of Mepivacaine Administered for Brachial Plexus Block in Patients With Chronic Renal Insufficiency

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01533545

Enrollment

Registered

2012-02-15

Start date

2012-09-30

Completion date

2014-09-30

Last updated

2014-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Insufficiency, Chronic

Keywords

Mepivacaine, Epinephrine, Brachial plexus block, Renal insufficiency

Brief summary

The aim of this study is to determine the effect of epinephrine on systemic absorption of local anaesthetic mepivacaine administered for brachial plexus block in uremic patients scheduled for creation or repair of an arteriovenous fistula. Furthermore, an impact of epinephrine on the central circulation and peripheral tissue oxygenation will be evaluated.

Interventions

DRUGMepivacaine with epinephrine

Ultrasound-guided infraclavicular brachial plexus block with mepivacaine 400 mg (10 mg/mL) mixed with epinephrine 200 μg (5 μg/mL)

DRUGPlain mepivacaine

Ultrasound-guided infraclavicular brachial plexus block with plain mepivacaine 400 mg (10 mg/mL)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient acceptance of regional anaesthesia

Exclusion criteria

* peripheral arteriosclerosis * diabetes mellitus * bleeding disorder * infection at the puncture site * allergy to mepivacaine * pregnancy

Design outcomes

Primary

Measure	Time frame
Plasma concentration of mepivacaine	0, 5, 10, 20, 30, 45, 60, 120, and 180 min after blockade

Secondary

Measure	Time frame	Description
Central circulation	0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min after blockade	Heart rate, blood pressure, cardiac output, stroke volume, and systemic vascular resistance
Peripheral tissue oxygenation	0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min after blockade	Near infrared spectrometry obtained from the triceps muscle of the blocked arm
Cardiotoxicity of local anesthetic	0, 5, 10, 20, 30, 45, and 60 min after blockade	12-lead ECG
Neurotoxicity of local anesthetic	Continuously for 1 hour after blockade	Visual and hearing disturbances, dysarthria, tingling, perioral numbness, dizziness, paraesthesia, muscular twitching and rigidity

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026