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The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention

The Impact of Psychopathic Traits on the Efficacy of a Brief Intervention for Substance Use

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01532934
Enrollment
105
Registered
2012-02-15
Start date
2009-08-31
Completion date
2014-07-31
Last updated
2016-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychopathy, Substance Use

Keywords

substance use, psychopathy, motivational enhancement, criminal recidivism

Brief summary

Substance use among criminal offenders constitutes a major public health problem and is tied to negative consequences for offenders, their families, and their communities. One of the direst of these consequences is repeated incarceration; thus, interventions that reduce criminal recidivism are needed. Forensic populations are often viewed with considerable therapeutic pessimism. However, offenders exhibit heterogeneity in personality traits, and the assessment of individual differences among offenders may provide valuable information that guides the use of psychotherapeutic interventions. Among offenders, psychopathy has emerged as an important personality construct for the understanding of violence and criminal recidivism. Moreover, core traits of psychopathy such as lack of empathy, deceitfulness, and lack of remorse may have negative implications for the efficacy of psychosocial interventions. A foundational premise of the present work is that understanding the moderating role of psychopathic traits on substance use treatment outcomes among offenders is essential to determining what works, and for whom. The current proposal is a Phase II randomized clinical trial that aims to examine the impact of psychopathic traits on the efficacy of a brief substance use intervention for offenders in a jail diversion program. Hypotheses that will be examined include: 1) that a Motivational Interviewing (MI) - based treatment will reduce substance use and related consequences relative to a Standard Care only condition, 2) that the reduction in substance use in the intervention group will mediate a reduction in later criminal recidivism relative to the Standard Care condition, and 3) that core psychopathic traits will moderate the efficacy of the intervention such that individuals with lower levels of these traits will derive greater benefits with regard to decreased substance use, decreased drug use consequences, and decreased criminal recidivism at a one-year follow-up.

Detailed description

Substance use among criminal offenders constitutes a major public health problem and is tied to negative consequences for offenders, their families, and their communities. One of the direst of these consequences is repeated incarceration; thus, interventions that reduce criminal recidivism are needed. Forensic populations are often viewed with considerable therapeutic pessimism. However, offenders exhibit heterogeneity in personality traits, and the assessment of individual differences among offenders may provide valuable information that guides the use of psychotherapeutic interventions. Among offenders, psychopathy has emerged as an important personality construct for the understanding of violence and criminal recidivism. Moreover, core traits of psychopathy such as lack of empathy, deceitfulness, and lack of remorse may have negative implications for the efficacy of psychosocial interventions. A foundational premise of the present work is that understanding the moderating role of psychopathic traits on substance use treatment outcomes among offenders is essential to determining what works, and for whom. The current proposal is a Phase II randomized clinical trial that aims to examine the impact of psychopathic traits on the efficacy of a brief substance use intervention for offenders in a jail diversion program. Hypotheses that will be examined include: 1) that a Motivational Interviewing (MI) - based treatment will reduce substance use and related consequences relative to a Standard Care only condition, 2) that the reduction in substance use in the intervention group will mediate a reduction in later criminal recidivism relative to the Standard Care condition, and 3) that core psychopathic traits will moderate the efficacy of the intervention such that individuals with lower levels of these traits will derive greater benefits with regard to decreased substance use, decreased drug use consequences, and decreased criminal recidivism at a one-year follow-up. This work has the potential to provide important data regarding which individuals can benefit from a brief intervention for substance use. Such data will inform the effective and efficient allocation of treatment resources for substance using offenders.

Interventions

BEHAVIORALmotivational enhancement therapy

Four 45-minute MET sessions

OTHERstandard care

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of Rochester
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* In local pretrial services program; English speaking

Exclusion criteria

* Psychosis, inability to provide informed consent

Design outcomes

Primary

MeasureTime frameDescription
Percent Days Abstinent Per Month From Drug Usethree to six months post baselineUsing timeline followback data, frequency of substance use was assessed for months three through six and presented as average percent days abstinent per month.

Secondary

MeasureTime frameDescription
Shortened Inventory of Problems With Alcohol and Drugs (SIP-AD)six monthsA measure of consequences of drug and alcohol use across several domains (e.g., social, work, health), SIP-AD scores range from 0-45, with higher scores indicating higher levels of substance use consequences.
New Criminal Chargeone yearNew criminal charge vs. no new criminal charge at follow-up as indicated by county database.

Countries

United States

Participant flow

Recruitment details

Recruitment took place at a jail diversion program in Upstate NY between 2009 and 2014.

Pre-assignment details

Inclusion criteria were harmful substance use in the past 6 months and enrollment in a jail diversion program subsequent to being charged with a crime.

Participants by arm

ArmCount
Brief Motivational Intervention Plus Standard Care (BMI+SC)
Brief Motivational Intervention plus Standard Care; Individuals received up to 4 intervention sessions plus assessment and the usual range of services provided by Monroe County Pretrial
53
Standard Care (SC)
Standard Care: Individuals received assessment only, plus the usual range of services provided by Monroe County Pretrial
52
Total105

Withdrawals & dropouts

PeriodReasonFG000FG001
Overall StudyIn controlled environment32
Overall StudyLost to Follow-up1111

Baseline characteristics

CharacteristicBrief Motivational Intervention Plus Standard Care (BMI+SC)Standard Care (SC)Total
Age, Continuous33.1 years
STANDARD_DEVIATION 10
33.8 years
STANDARD_DEVIATION 11.8
33.4 years
STANDARD_DEVIATION 10.9
Psychopathy Checklist-Revised - Factor One (F1)8.1 units on a scale
STANDARD_DEVIATION 4.3
9.0 units on a scale
STANDARD_DEVIATION 4.4
8.6 units on a scale
STANDARD_DEVIATION 4.3
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants0 Participants0 Participants
Race (NIH/OMB)
Asian
0 Participants0 Participants0 Participants
Race (NIH/OMB)
Black or African American
21 Participants24 Participants45 Participants
Race (NIH/OMB)
More than one race
8 Participants2 Participants10 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants0 Participants0 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants
Race (NIH/OMB)
White
24 Participants26 Participants50 Participants
Region of Enrollment
United States
53 participants52 participants105 participants
Sex: Female, Male
Female
23 Participants14 Participants37 Participants
Sex: Female, Male
Male
30 Participants38 Participants68 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
— / —— / —
other
Total, other adverse events
0 / 530 / 52
serious
Total, serious adverse events
0 / 530 / 52

Outcome results

Primary

Percent Days Abstinent Per Month From Drug Use

Using timeline followback data, frequency of substance use was assessed for months three through six and presented as average percent days abstinent per month.

Time frame: three to six months post baseline

Population: 105 adults (68 men and 37 women) were recruited in an urban pretrial jail diversion program. 78 (74.3%) were retained through six months. Of these, 73 were out of controlled environments (e.g., jail, inpatient treatment) for long enough to have their substance use data analyzed.

ArmMeasureValue (MEAN)Dispersion
BMI+SCPercent Days Abstinent Per Month From Drug Use46.92 percentage of days abstinentStandard Deviation 37.46
Standard CarePercent Days Abstinent Per Month From Drug Use55.16 percentage of days abstinentStandard Deviation 42.09
Comparison: A priori hypothesis. Psychopathy Factor 1 (F1) X treatment interaction to predict higher substance use among people high in F1 + who get treatment relative to individuals with high F1 who get standard care.p-value: 0.02Regression, Linear
Secondary

New Criminal Charge

New criminal charge vs. no new criminal charge at follow-up as indicated by county database.

Time frame: one year

ArmMeasureValue (NUMBER)
BMI+SCNew Criminal Charge23 participants
Standard CareNew Criminal Charge22 participants
Comparison: Experimental hypothesis: Treatment X F1 interaction will predict fewer charges at one-year follow-up for individuals low on F1 who got treatment relative to individuals low on F1 who did not.p-value: 0.69Regression, Logistic
Secondary

Shortened Inventory of Problems With Alcohol and Drugs (SIP-AD)

A measure of consequences of drug and alcohol use across several domains (e.g., social, work, health), SIP-AD scores range from 0-45, with higher scores indicating higher levels of substance use consequences.

Time frame: six months

ArmMeasureValue (MEAN)Dispersion
BMI+SCShortened Inventory of Problems With Alcohol and Drugs (SIP-AD)10.69 units on a scaleStandard Deviation 13.21
Standard CareShortened Inventory of Problems With Alcohol and Drugs (SIP-AD)15.24 units on a scaleStandard Deviation 14.28
Comparison: Experimental hypothesis: The F1 X treatment interaction will show that individuals low on F1 who get treatment will reduce substance use consequences at six months relative to those low on F1 who get standard care.p-value: 0.34Regression, Linear

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026