Low Oxygen Tension
Conditions
Brief summary
This study will determine whether the use of low oxygen tension during in vitro embryo culture may increase the pregnancy rates in women undergoing egg donation.
Detailed description
As far as oxygen (O2) tension is concerned, both oocytes and embryos from different mammalian species included the human are normally surrounded by values which are much less than half of atmospheric O2, ranging from high (8.7% O2) in the rabbit oviduct, rabbit and hamster uterus, to as low as 11 mm Hg (1.5% O2) in the monkey uterus. Even in the preovulatory follicle, oocytes are bathed within follicular fluids containing oxygen that range from \> 1 to 5.5 % The aim of this study was to evaluate the impact the effect of low oxygen tension after day-3 embryo transfer in our egg donation programme on pregnancy and implantation rates.
Interventions
OTHERDecreased oxygen concentration
The oxygen concentration is decreased during the in Vitro embryo culture.
Sponsors
Instituto Valenciano de Infertilidad, IVI VALENCIA
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Women aged 25-45 years of age; * In good mental and physical health; * First or second of egg-recipient treatment; * Embryo transfer on Day 3. * One to three embryos will be transferred. * BMI between 18-25 kg/m2.
Exclusion criteria
* Uterine pathology or hydrosalpinx * Recurrent miscarriage * No chronic illnesses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rates per cycle | one month |
Countries
Spain
Outcome results
None listed