PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea

Conditions

Obstructive Sleep Apnea Syndrome

Keywords

OSAS, American Academy of Sleep Medicine Task Force

Brief summary

The present research intends to focus clinically on selecting the right type of patient for mandibular advancement devices (MAD) therapy using screening tools such as advanced imaging and computational methods based on CT-Scan images as well as drug-induced sleep nasendoscopy techniques with simulation of the mandibular repositioning. The core of the research project relies on known and established methods accepted in several neighboring fields, but aims at the transfer of this knowledge by integrating it into this new domain. Doing so, the proposed biomedical research is directed towards clinical applications that incorporate innovative developments on the level of the diagnosis and therapy of a specific disease, being obstructive sleep apnea syndrome (OSAS). Furthermore, this study aims at registering objective compliance during MAD therapy.

Van Gaver H, Op de Beeck S, Dieltjens M, De Backer J, Verbraecken J, De Backer WA, Van de Heyning PH, Braem MJ, Vanderveken OM.

2022-03-0116 citations

10.5664/jcsm.9694

Mandibular Advancement Device Treatment Efficacy Is Associated with Polysomnographic Endotypes.

Op de Beeck S, Dieltjens M, Azarbarzin A, Willemen M, Verbraecken J, Braem MJ, Wellman A, Sands SA, Vanderveken OM.

2021-03-0142 citations

10.1513/annalsats.202003-220oc

The relationship between specific nasopharyngoscopic features and treatment deterioration with mandibular advancement devices: a prospective study.

Van de Perck E, Op de Beeck S, Dieltjens M, Vroegop AV, Verbruggen AE, Willemen M, Verbraecken J, Van de Heyning PH, Braem MJ, Vanderveken OM.

2020-07-017 citations

10.5664/jcsm.8474

Phenotypic Labelling Using Drug-Induced Sleep Endoscopy Improves Patient Selection for Mandibular Advancement Device Outcome: A Prospective Study.

Op de Beeck S, Dieltjens M, Verbruggen AE, Vroegop AV, Wouters K, Hamans E, Willemen M, Verbraecken J, De Backer WA, Van de Heyning PH, Braem MJ, Vanderveken OM.

2019-08-0156 citations

10.5664/jcsm.7796

Determinants of Objective Compliance During Oral Appliance Therapy in Patients With Sleep-Related Disordered Breathing

Marijke Dieltjens, Annelies E. Verbruggen, M. Braem, Kristien Wouters, Johan Verbraecken et al. (9 authors)

JAMA Otolaryngology–Head & Neck Surgery2015-09-2461 citations

10.1001/jamaoto.2015.1756

Interventions

DEVICEMandibular Advancement Device ( MAD)

Study design

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Age ≥ 18 years * body mass index (BMI) ≤ 35 kg/m² * OSAS, as defined by the American Academy of Sleep Medicine Task Force * apnea-hypopnea index (AHI) \< 50

Exclusion criteria

* Other sleep disorders (i.e. parasomnias) * Invasive upper airway surgery for sleep-disordered breathing * Known genetic disorders with craniofacial and/or upper airway malformations * Use of benzodiazepine and/or antidepressants * Known history of psychiatric disease * Known history of fibromyalgia and/or chronic fatigue syndrome * Dental contra-indications: functional restrictions of the temporomandibular joint, insufficient dentition with pathological changes, insufficient retention for MAD use

Design outcomes

Primary

Measure	Time frame	Description
Predictive value of DISE and CFD	3 months	Positive and negative predictive values for AHI based treatment outcome

Countries

Belgium

Outcome results

None listed