Anesthesia, Intravenous, Anesthesia Recovery Period
Conditions
Keywords
Emergence, Hypercapnia, Hypocapnia, Propofol
Brief summary
Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.
Interventions
PROCEDURERebreathing tube
750 ml rebreathing tube will be connected between the corrugated tube and the tracheal tube of a patient. Target partial pressure of the end-tidal carbon dioxide is 50 mmHg.
PROCEDURENo rebreathing tube (Nothing)
750 ml rebreathing tube will not be connected between the corrugated tube and the tracheal tube of a patient. Target partial pressure of the end-tidal carbon dioxide is 30 mmHg.
Sponsors
DongGuk University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists physical status (ASA PS) I-II * Age 20 - 60 years male and female * Elective schedule with minor surgery under general anesthesia
Exclusion criteria
* Body mass index (BMI) \>= 30 (kg/m2) * Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history * Patient with medication affecting on this study * Patient with general anesthesia history within one month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to open eyes under investigator's command | From cessation of propofol infusion to patient's eye opening (seconds) | After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, Open your eyes. When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to breath spontaneously | From cessation of propofol infusion to patient's spontaneous breathing (sec) | The time from cessation of propofol infusion to patient's spontaneous breaths will be recorded. The patients will be followed for an expected average of 10 minutes. |
| Change of bispectral index (BIS) | From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded. | After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes. |
| Time to open mouth under investigator's command | From cessation of propofol infusion to patient's mouth opening (seconds) | After the patient opens the eyes, every 10 seconds, the investigator command the patient, Open your mouth.. When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 12 minutes. |
| Time to extubation | From cessation of propofol infusion to extubation (sec) | After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes. |
Countries
South Korea
Outcome results
None listed