3D Breast Ultrasound Elastography in Patients Under Neoadjuvant Chemotherapy

Imagerie 3D d'élasticité du Sein Par échographie Ultrarapide au Cours d'un Traitement Par chimiothérapie néoadjuvante.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01531036

Enrollment

Registered

2012-02-10

Start date

2010-12-31

Completion date

2012-11-30

Last updated

2025-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant Breast Tumours

Brief summary

Breast Ultrasound Elastography is a complementary technique permitting a better characterization of breast lesions. 3D breast ultrasound elastography is a novel technique permitting a volumetric calculation of lesion stiffness. This could be particularly useful in patients with large breast tumors under pre-operative chemotherapy

Detailed description

3D breast ultrasound elastography provides volumetric lesion stiffness details in real time. 3D acquisition is compared to breast MRI in order to evaluate volume measurements calculated in ultrasound. Lesion elasticity is calculated in 3 planes with immediate reconstruction. The purpose of this prospective study is to evaluate the feasibility of this technique and compare the results to those of Breast MRI. For women receiving preoperative chemotherapy, this technique will be evaluated with regard to tumour shrinkage and lesion elasticity modifications under treatment.

Interventions

DEVICE3D Ultrasound elastography by means of shear wave propagation into breast tissue

Aixplorer Supersonic Imagine Ultrasound System with 3D probe for real-time elastography

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients having already undergone a breast MRI * Patients presenting with breast lesions measuring between20-50mm in ultrasound

Exclusion criteria

* Multifocal lesions * History of breast cancer * Breast implants * Inflammatory breast disease * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
3D volumetric elasticity measurements	10min	An utrafast shear wave imaging 3-plane acquisition provides several frames of breast lesion elasticity, that are reconstructed by means of a dedicated software thus permitting the direct volumetric elasticity measurements in kPa

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026