Temporary Clipping of the Uterine Arteries During Laparoscopic Myomectomy

Reduction of Intraoperative Blood Loss During Laparoscopic Myomectomy by Temporary Clipping of the Uterine Arteries

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01530802

Enrollment

166

Registered

2012-02-10

Start date

2007-01-31

Completion date

2009-12-31

Last updated

2012-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Myomectomy, Leiomyoma

Keywords

laparoscopic myomectomy, leiomyoma, blood loss, uterine artery

Brief summary

The aim is to verify, whether intraoperative temporary clipping of the uterine vessels with vascular clips can reduce blood loss significantly.

Interventions

PROCEDUREclipping of uterine arteries during laparoscopic myomectomy

For laparoscopy standard instruments were used.For vascular clamping we used titan made YASARGIL vessel clips. The patient is put in a 20° Trendelenburg. The surgeon coagulates a 3-4 cm long segment of peritoneum over the ileopsoas muscle. Along the coagulated segment the peritoneum is opened. The surgeon identifies the ureter at its crossing over the common iliac vessels. After medializing the ureter, the pararectal space is opened and the internal iliac artery is identified and dissected till the origin of the uterine artery. The uterine artery is isolated over a distance of about 2 cm. The vascular clip is placed over the uterine artery. Yasargil Clips are applied exclusively in patients of intervention group. Myomectomy is performed in identical fashion in both groups. At the end of myomectomy the vessel clips are removed. The metroplasty is controlled for hemostasis after reopening of the uterine vessels.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Patients are eligible for the study when between 18 and 50 years of age, * diagnosed with either symptomatic or asymptomatic leiomyomata, and with desire to keep the uterus, and whose leiomyomata had a minimal combined diameter of ≥ 4 cm.

Exclusion criteria

* patients with severe accompanying medical problems, or * with psychiatric illnesses, which jeopardize the participation, or * undergoing treatment affecting coagulation and/or hematopoiesis, and * patients with suspected malignancy.

Design outcomes

Primary

Measure	Time frame	Description
Blood loss during laparoscopic myomectomy	perioperative (preop and postoperative day3)	hemoglobin drop transfusion rate

Secondary

Measure	Time frame	Description
Patency of uterine artery after laparoscopic clipping	perioperative	Doppler results of the uterine arteries

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026