Obesity
Conditions
Keywords
abdominal obesity
Brief summary
The investigators hypothesize that differential dynamics in fat depots in response to two opposing dietary strategies mediate the beneficial metabolic effects during weight loss and regain phases.
Interventions
Weight-loss diet strategy with a free gym membership; monthly 60-minute educational workshops; 3 sessions of workout per week of mostly aerobic training
Weight-loss diet strategy without exercise
Sponsors
Study design
Eligibility
Inclusion criteria
* Elevated waist circumference: * Men: \> 40 inches (102 cm) * Women\> 35 inches (88 cm) * Poor dieters with TG\>150mg/dL and high-density-lipoprotein cholesterol \[HDL-c\] \<40 mg/dL for men and \<50 mg/dL for women
Exclusion criteria
* Pregnant or lactating women * Serum creatinine LT 2 mg/dl * Disturbed liver function (LT 3 fold level of ALT and AST enzymes) * Active cancer * Individuals who cannot start physical activity in the gym * Individuals that are highly physically active (more than 4 hours/week) * Active in other nutritional trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| body fat composition | 0, 6,18 months | changes in body fat (MRI) |
| obesity | 0, 6, 18 months | changes in weight |
| abdominal obesity | 0, 6, 18 months | changes in waist circumference |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory state | 0, 6, 18 months | Changes hsCRP (mg/L) (blood draw) |
| Metabolomic | 0, 6, 18 months | Changes in sub-lipids (blood draw) |
| Epigenetics | 0, 6, 18 months | changes in genes' methylation (blood draw) |
| Genetic signature | baseline | SNPs (variants) associated with fat distribution and visceral fat (blood draw) |
| Liver function (blood biomarkers) | 0, 6, 18 months | Changes in ALT (U/l), AST (U/l), ALKP (U/I), GGT (U/l) (blood draw) |
| Lipid profile | 0, 6, 18 months | Changes in lipid biomarkers: total cholesterol (mg/dL), triglycerides (mg/dL), HDLc (mg/dL), LDLc (mg/dL) (blood draw) |
| Glycemic control | 0, 6, 18 months | Changes in fasting glucose (mg/dL) (blood draw) |
Countries
Israel