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Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals

Molecular Events Underpinning Changes in Tissue Metabolism With Whey and Soy Ingestion in Energy Restriction in Overweight/Obese Adults

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01530646
Enrollment
42
Registered
2012-02-10
Start date
2012-02-29
Completion date
2013-05-31
Last updated
2015-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

obesity, overweight, muscle, protein, muscle protein synthesis, muscle protein breakdown, whey, soy, caloric restriction

Brief summary

It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass. When exercise is not included in a period of restricted energy intake, the degree to which muscle mass is lost is highly dependent upon protein consumption. Whey protein is a high quality protein isolated from milk and is known to stimulate new protein synthesis for all proteins in your body. Previous research has established that the consumption of whey protein has been correlated with retaining muscle mass while stimulating fat loss. However, the mechanisms behind these findings is still unknown. The purpose of this study is to establish a mechanistic underpinning to the efficacy of whey protein versus soy protein and a carbohydrate control (maltodextrin), in promoting fat mass loss and lean mass retention during a period of short-term controlled dietary energy deficit (-750 kcalories/day).

Interventions

BEHAVIORALWeight loss

-750kcal/d

DIETARY_SUPPLEMENTSoy

2 x 25g/d SPC

DIETARY_SUPPLEMENTWhey

2 x 25g/d WPI

Sponsors

McMaster University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Aged 35 to 55 years old * Moderately Obese/Overweight (body mass index \> 25 and \< 42 kg/m2) * Healthy * Non-smoker

Exclusion criteria

* Suffer from type 2 diabetes, hyperlipidemia, or thyroid dysfunction * Taking medications * Having an unstable weight in the past 4-6 months, or dieting at some time during the past 6 months * Taking weight loss products or aids (including energy drinks)

Design outcomes

Primary

MeasureTime frame
Muscle protein synthesis rate and lipolytic rate as measured using stable isotope and glycerol infusions.After 14 day dietary intervention

Secondary

MeasureTime frame
Transcriptomic changes (via gene profiling) associated with the effects of whey on lipogenic and lipid oxidative genes, and protein synthetic pathways in muscle.After 14 days of dietary intervention

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 18, 2026