Complications Associated With Artificial Fertilization, Disorder of Endocrine Ovary
Conditions
Keywords
IVF, ovarian hyperstimulation syndrome, cabergoline, hydroxyethyl starch, prevention
Brief summary
The purpose of this study is to assess whether, in GnRH agonist in vitro fertilization (IVF) cycles, where there is a risk of ovarian hyperstimulation syndrome (OHSS), the addition of cabergoline to the hydroxyethyl starch infusion could decrease OHSS incidence and severity.
Detailed description
Women undergoing IVF cycles with GnRH agonist protocols, at risk of OHSS (more than 20 follicles observed larger than 12 mm in diameter and/or estradiol levels of 3000-5000 pg/mL). Slow infusion of 500 ml of 6% HES during follicular aspiration alone or combined with 0.5 mg cabergoline administration for 8 days, starting on the day of hCG administration.
Interventions
DRUGCabergoline and Hydroxyethyl Starch
0.5mg
0.5 mg cabergoline administration 8 days
Sponsors
Hospital de Cruces
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* to be at risk of OHSS were invited to participate in the study
Exclusion criteria
* age \> 40 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| risk of ovarian hyperstimulation syndrome | 12 days |
Secondary
| Measure | Time frame |
|---|---|
| pregnancy rate | 15 days |
Outcome results
None listed