Amyotrophic Lateral Sclerosis
Conditions
Keywords
Amyotrophic lateral sclerosis
Brief summary
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that involves not only motor structures, as was previously thought, but also brain areas dealing with cognition as well as parts of the limbic system. Clinical, imaging and pathological evidence suggests that ALS and fronto-temporal dementia (FTD) have several features in common, and that these two diseases could be the two ends of a pathological continuum.
Detailed description
Objectives : the investigators aim to study the clinical profile and magnitude of cognitive disturbances, measure brain metabolism and assess cerebral atrophy in patients with ALS. The relationships between cognitive, metabolic and anatomical data will be determined by the correlation method. In addition, pathological studies will be carried out in deceased patients having given their consent in advance, in order to quantify the neuronal loss and UBIs. Methods : the investigators plan to recruit 60 patients with ALS, 10 patients with ALS/FTD (the diagnosis of dementia will rest on clinical data and formal neuropsychological testing) and 20 normal control subjects. The ALS patients will be divided into 2 subsets on the basis of a preliminary neuropsychological work-up, according to the presence or absence of subclinical cognitive impairment as defined by abnormal scoring on tests not meeting the criteria for dementia. In a second testing session carried out at the same time, a comprehensive assessment of memory, behaviour and emotional changes will be done. All subjects will then undergo morphological magnetic resonance imaging (MRI), resting-state functional MRI and 18-fluorodeoxyglucose positron emission tomography (18FDG-PET). Whenever possible, a second testing session will be carried out 9 to 12 months later in order to quantify the cognitive deterioration, if any, and to find early predictors of the evolution towards dementia. In deceased patients, the location and extent of neuronal loss will be determined, as well as the location and number of UBIs. Results and clinical relevance : this study is intended to improve our knowledge of the clinical phenotype of ALS, and particularly to learn more about the extent of cognitive, behavioural and emotional changes in this disease. This could in turn shed some further light on the relationships between ALS and FTD.
Interventions
OTHERMRI + 18FDG-PET + neuropsychological assessments ; 18FDG performed especially for the research
At T0 and T9 or 12 monts, are performed : * Imaging : fMRI at rest and anatomical MRI * Neuropsychological assessments : general cognitive functioning, theory of mind, executive functions ...
Sponsors
University Hospital, Caen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* All participants : * study level \> 7 years * mother tongue : french * signature of the informed consent of the protocol in accord with the Comité de Protection des Personnes * medical, neurological, neuroradiological and neuropsychological approfondis in accord with the specific inclusion and non inclusion criteria spécifiques at each population * Patients ALS : * 18 to 80 years old * Diagnostic defined or probable in according to the reviewed criteria of El Escorial. * Patients ALS / FTD : * 18 to 8O years old * Diagnostic defined or probable in according to El Escorial reviewed criteria and diagnostic of frontal-temporal dementia in according to Lund et Manchester criteria. * Control Subjects : * 45 to 75 years old * DRS ≥ 130 * BECK \< 8
Exclusion criteria
* All particpants : * Major past history (chronic pulmonary disease, cardiac disease, metabolic, haematological, endocrinological or severe immunological, cancer) ; * Chronic use of alcohol or drugs ; * IRM contraindications Protected adults, and persons non affiliated to social protection system won't be able to participate at this study. The inclusion of the participant in another biomedical research protocol(during the study or into 12 months before the inclusion) is too a non inclusion criterion. * Patients SLA and patients SLA / FTD * Severe bulbar disorders * Severe restrictive respiratory insufficiency (VC\<50%) with orthopny * Communication disorders with motor origin (non assessable tests) * Control Subjects : * Pregnant or nursing women * Unability to submit at the study medical follow-up for geographic or psychiatric reasons(previous or ongoing). * DRS score \< 130 * Depressive syndrome (BECK) ≥ 8
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive, behavioural and emotional changes assesed with Neuropsychological tests. | Between 9 and 12 mth |
Secondary
| Measure | Time frame |
|---|---|
| brain imaging (anatomical MRI, functional MRI, PET using 18FDG) | Between 9 and 12 mth |
Countries
France
Outcome results
None listed