ST- Depression on Electrocardiogram During Caesarean Section in Regional Anaesthesia in Women With Preeclampsia

Randomised Study on Cardiac Effects of Oxytocin During Caesarean Section in Preeclamptic Women

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01530230

Enrollment

Registered

2012-02-09

Start date

2005-11-30

Completion date

2008-04-30

Last updated

2012-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia

Keywords

cesarean section, electrocardiography, heart, hypotension, ischemia, oxytocin, preeclampsia, regional anesthesia, ECG changes suggestive of myocardial ischemia

Brief summary

The investigators examined whether there was a difference in the occurrence of ST depressions after injection of five or ten units of oxytocin, in preeclamptic patients delivered by caesarean section (CS) under regional anesthesia.

Detailed description

ST depression on electrocardiograms has been reported in healthy women undergoing cesarean section in regional anesthesia. The investigators examined whether there was a difference in the occurrence of electrocardiogram changes suggestive of myocardial ischemia (ST depressions) in preeclamptic patients randomized to five or ten units of oxytocin during cesarean section with regional anesthesia. In a double-blind randomized controlled study preeclamptic patients undergoing cesarean section under spinal anesthesia were randomized to 5 or 10 units of oxytocin, given as an intravenous bolus. A Holter monitor was used to record electrocardiograms. Non-invasive blood pressure and heart rate were monitored.

Interventions

DRUGoxytocin

Intravenous bolus dose given during 1 minute after clamping of the umbilical cord

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* women with preeclampsia undergoing CS under spinal anesthesia. Preeclampsia was diagnosed if blood pressure was ≥ 140/90 mm Hg and if proteinuria of more than 1000 mg/day persisted.

Exclusion criteria

* multiple birth, * obesity (body mass index \> 35), * age \< 18 years, * complications of the pregnancy other than preeclampsia or non-proficiency in the Swedish language

Design outcomes

Primary

Measure	Time frame
Depression of the ST segment on electrocardiograms	From start of caesarean section until 20 minutes after delivery

Secondary

Measure	Time frame
Mean arterial pressure and heart rate.	From start of caesarean section until 20 minutes after delivery

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026