Adaptation Reaction
Conditions
Keywords
cardiac, vascular, muscular, adaptations, soccer training, strength training
Brief summary
A one-year intervention study of 41 healthy elderly men aged 65-75-years.Of these, 24 subjects are untrained men with no regular training activity for the last 5 years. After medical screening and pre-testing, they will be randomized into a football group (n=9), a strength-training group (n=9) or a sedentary control group (n=6). Additional 17 subjects are recruited from local football clubs and have been active football players for the last 40 years. Training will be performed 3x1 hour per week and evaluation will take place after 0, 3 and 12 months. Primary endpoints will be changes in cardiac and vascular structure and function measured by advanced echocardiography (tissue Doppler and speckle tracking imaging), and peripheral arterial tonometry (Endo---PAT device). Secondary endpoints will be evaluation of potential changes in VO2 max, blood pressure, muscle capillaries, lipid profile, circulating catecholamines, body composition, and insulin resistance.
Interventions
training
Sponsors
Study design
Eligibility
Inclusion criteria
* 65-75 year old men * healthy * non-smoking * non-hypertension * non- cardiac disease
Exclusion criteria
* smoking * cardiac disease * biomechanical disorders * cardiac medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiac adaptations | after 16 weeks and one year | changes in cardiac function after 16 weeks and one year measured by advanced echocardiography (tissue Doppler and speckle tracking imaging) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiorespiratory fitness, muscular adaptations, Bloodpressure and Glucose tolerance | after 16 weeks and one year | Improvements in cardiorespiratory fitness assessed with VO2 max treadmill testing. Changes in muscular tissue with biopsies from the vastus lateralis muscle. Changes in resting blood pressure in incline postion Changes in glucose tolerance with oral glucose tolerance testing |
Countries
Denmark