Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01528956

Enrollment

Registered

2012-02-08

Start date

2012-02-29

Completion date

Unknown

Last updated

2016-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenocortical Carcinoma

Keywords

adrenocortical carcinoma

Brief summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

Detailed description

OBJECTIVES: * To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells. OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Interventions

GENETICDNA methylation analysis

GENETICRNA analysis

GENETICgene expression analysis

GENETICnucleic acid sequencing

GENETICpolymorphism analysis

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 21 Years

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Identification of genetic factors affecting adrenocortical tumors	—
Comprehensive catalog of altered genes in adrenocortical samples	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026