Phenotypes and Vascular Damage in Chronic Obstructive Pulmonary Disease (COPD)

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD, Cardiovascular disease, Phenotypes

Brief summary

TOPDOCS is a prospective cohort study including COPD patients from currently six study centers in Switzerland. Patients with COPD GOLD stages I-IV will be enrolled and followed-up annually for at least 3 years. Yearly assessments will include a detailed patient history, quality of life and activity questionnaires, history of exacerbations, lung function, measurements of exercise capacity, measurements of vascular function, exhaled breath analysis and blood sampling. The overall objective of the project is to establish a meticulously characterized cohort of COPD patients living in Switzerland in order to allow high quality research on the pathogenesis, treatment and complications of COPD. The specific aim of the project is to determine clinically relevant COPD phenotypes and biological factors influencing vascular function in COPD patients.

Noriane A. Sievi, Thomas Brack, Martin Brutsche, Martin Frey, Sarosh R. Irani et al. (9 authors)

Respiratory Research2020-01-2013 citations

10.1186/s12931-020-1290-9

<p>Arterial Stiffness Increases Over Time in Relation to Lung Diffusion Capacity: A Longitudinal Observation Study in COPD</p>

Maurice Roeder, Noriane A. Sievi, Dario Kohlbrenner, Christian F. Clarenbach, Malcolm Kohler

International Journal of COPD2020-01-0112 citations

10.2147/copd.s234882

<p>No impact of exacerbation frequency and severity on the physical activity decline in COPD: a long-term observation</p>

Noriane A. Sievi, Malcolm Kohler, Robert Thurnheer, Jörg D. Leuppi, Sarosh R. Irani et al. (9 authors)

International Journal of COPD2019-02-0110 citations

10.2147/copd.s188710

Physical activity declines in COPD while exercise capacity remains stable: A longitudinal study over 5 years.

Sievi NA, Brack T, Brutsche MH, Frey M, Irani S, Leuppi JD, Thurnheer R, Kohler M, Clarenbach CF.

2018-06-1818 citations

10.1016/j.rmed.2018.06.013

Annual progression of endothelial dysfunction in patients with COPD.

Clarenbach CF, Sievi NA, Kohler M.

2017-09-1812 citations

10.1016/j.rmed.2017.09.005

Physical inactivity and arterial stiffness in COPD

Christian F. Clarenbach, Daniel Franzen, Malcolm Kohler, Noriane A. Sievi

International Journal of COPD2015-09-0130 citations

10.2147/copd.s90943

Impact of comorbidities on physical activity in <scp>COPD</scp>

Noriane A. Sievi, Oliver Senn, Thomas Brack, Martin Brutsche, Martin Frey et al. (11 authors)

Respirology2015-01-0666 citations

10.1111/resp.12456

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

No

Inclusion criteria

* Proven COPD (GOLD stages I-IV) * Age: 40-75 years

Exclusion criteria

* Mental or physical disability precluding informed consent or compliance with the protocol * Acute or recent (within the last 6 weeks) exacerbation of COPD

Design outcomes

Primary

Measure	Time frame	Description
Lung function	The change from baseline in lung function at 3 years	FEV1

Secondary

Measure	Time frame	Description
Exacerbations	The number of exacerbations observed within 3 years	Number of COPD exacerbations observed within 3 years of observation
Cardiovascular risk score	The change from baseline in risk score function at 3 years	Pocock score
BODE-index	The change from baseline in BODE-index at 3 years	BODE-Index
Quality of life	The change from baseline in quality of life scale at 3 years	Quality of life scales
Activity	The change from baseline in activity at 3 years	Actigraphy
Hear Arterial Stiffness	The change from baseline in arterial stiffness at 3 years	Arterial stiffness by pulse wave analysis
Endothelial Function	The change from baseline in endothelial function at 3 years	Endothelial function assessed by flow-mediated dilatation (FMD)
Exercise capacity	The change from baseline in exercise capacity at 3 years	6 minute walking test and sit-to-stand test
Blood pressure	The change from baseline in mean blood pressure at 3 years	Mean blood pressure

Countries

Switzerland

Outcome results