Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress

The Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress in Healthy But Overweight/Obese Subjects: A Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01527617

Enrollment

Registered

2012-02-07

Start date

2012-02-29

Completion date

2013-02-28

Last updated

2016-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Brief summary

The objective of this randomized, double-blind, placebo-controlled, parallel-design clinical trial is to investigate the potential antioxidant benefits of a cranberry beverage. The investigators hypothesize the chronic consumption of this beverage will improve indices of oxidative stress, inflammation, endothelial function, and glucoregulation. The investigators also hypothesize that these benefits will be particularly evident following an oral glucose tolerance test.

Interventions

OTHERCranberry

beverage containing cranberry at a dose of 15.2 ounces per day for 56 days.

OTHERNon-Cranberry beverage

Placebo Comparator - beverage absent cranberry at a dose of 15.2 ounces per day for 56 days.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Men & women, aged 30-70 years * BMI 27-34.9 kg/m2 * waist:hip ratio \> 0.8 for women and \> 0.9 for men

Exclusion criteria

* Cigarette smoking and/or nicotine replacement use within last 6 months * Individuals taking estrogen or testosterone * Use of cholesterol-lowering medications * Use of blood pressure-lowering medications * Regular use (\> 1x/wk) of any stomach acid-lowering medications or laxatives (including fiber supplements) * Cardiovascular (heart) disease * Gastrointestinal disease * Kidney disease * Endocrine disease: including diabetes, untreated thyroid disease * Rheumatoid arthritis * Immune deficiency conditions * Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission * Systolic blood pressure \> 139 mmHg and/or diastolic blood pressure \> 89 mmHg * Regular use of systemic steroids, oral or injectable * Regular daily intake of ≥ 2 alcoholic drinks * Infrequent (\< 3/week) or excessive (\> 3/d) number of regular bowel movements * Gain or loss of ≥ 5% of body weight in the last 6 months * Pregnancy * Strict vegetarians * No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission

Design outcomes

Primary

Measure	Time frame
Change in biomarkers of inflammation compared with placebo	Baseline and 8 weeks
Change in biomarkers of oxidative stress compared with placebo.	Baseline and 8 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026