Achalasia, Hypertensive LES
Conditions
Keywords
Achalasia, Hypertensive LES
Brief summary
Spastic esophageal motility disorders induced significant symptoms including dysphagia, retrosternal pain and regurgitation. Per oral endoscopic myotomy (P.O.E.M.) is a novel approach to perform myotomy through the esophagus with long submucosal tunnel. This study aimed to investigate the feasibility and safety of P.O.E.M. and translate the techniques from animal study to clinical practice in human.
Interventions
PROCEDUREPer Oral Endoscopic Myotomy
Sponsors
Chinese University of Hong Kong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All patients with age ranged 18 to 80 who had primary esophageal motility disorders will be recruited. The primary motility disorders included: Achalasia, hypertensive LES, Nutcracker esophagus and Diffuse esophageal spasm.
Exclusion criteria
* Patients will be excluded from this study with the followings - 1. Pregnancy 2. Informed consent not available 3. Previous history of esophagectomy or mediastinal surgery 4. Previous history of endoscopic resection for early esophageal cancers, including endoscopic mucosal resection and endoscopic submucosal dissection 5. End-stage Achalasia with dilated esophagus more than 6cm on Barium swallow
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dysphagia score before and after P.O.E.M. | From 1st day after POEM to within 2 weeks after POEM |
Secondary
| Measure | Time frame |
|---|---|
| Eckardt score before and after P.O.E.M. | Before and 1 month after POEM |
| Post-operative pain | From Day 1 to until 2 weeks after POEM |
| Operative time | Up to 24 hours |
| Hospital stay | From day of admission till up to 30 days |
| Perioperative complication | 30 days after operation |
Countries
Hong Kong
Outcome results
None listed