Obesity
Conditions
Brief summary
Objective: It is unclear whether prolonged electrical muscle stimulation can improve cardiorespiratory fitness and reduce body fat in obese subjects. The purpose of this study is to investigate the effect of prolonged combined thermal and electrical muscle stimulation (cTEMS) on peak oxygen consumption (VO2 peak) and body composition. We will also investigate the biochemical effects and the resultant lipolysis-related gene expression changes in adipocytes. Methods:Eleven obese (BMI≥30) individuals will receive cTEMS in three 60-minute sessions per week for 8 weeks. Activity levels and dietary habits will be kept unchanged and controlled with an accelerometer and nutritional questionnaire. Before and after the stimulation period, functional capacity are assessed by VO2 peak, and body composition was assessed by dual-energy X-ray absorptiometry and bioelectrical impedance analyses. Lipolytic activity will be determined in abdominal adipose tissue by 24 hours of microdialysis on a sedentary day, and adipose tissue biopsies will be taken for the gene expression analysis.
Interventions
DEVICEcombined thermal and electrical muscle stimulation (cTEMS)
cTEMS in three 60-minute sessions per week for 8 weeks
Sponsors
University of Bergen
Haukeland University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Obese (Body mass index; BMI ≥ 30 kg/m2), * sedentary subjects (\< 20 minutes of exercise \< 3 days per week). * Other inclusion criteria were age between 30 and 70 years and * the ability to undergo exercise testing.
Exclusion criteria
* Pacemaker or implanted defibrillator, * regular medication, * cardiovascular disease, * pulmonary disease, * extensive dermatological disease or other primary diseases; * pregnant women; * and individuals who abuse alcohol or drugs were excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygen uptake | Baseline and after 10 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipolytic activity | Baseline and after 10 weeks | Lipolytic activity in adipose tissue measured by microdialysis |
| Gene expression in adipose tissue | Baseline and after 10 weeks | — |
| Body composition | Baseline and after 10 weeks | Body composition by DEXA |
Countries
Norway
Outcome results
None listed