Achalasia
Conditions
Keywords
Hypertensive LES
Brief summary
Spastic esophageal motility disorders induced significant symptoms including dysphagia, retrosternal pain and regurgitation. Per oral endoscopic myotomy (P.O.E.M.) is a novel approach to perform myotomy through the esophagus with long submucosal tunnel. This study aimed to investigate the feasibility and safety of P.O.E.M. and translate the techniques from animal study to clinical practice in human.
Interventions
PROCEDUREPer Oral Endoscopic Myotomy
Sponsors
Chinese University of Hong Kong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* All patients with age ranged 18 to 80 who had primary esophageal motility disorders will be recruited. The primary motility disorders included: Achalasia, hypertensive LES, Nutcracker esophagus and Diffuse esophageal spasm.
Exclusion criteria
* Patients will be excluded from this study with the followings - 1. Pregnancy 2. Informed consent not available 3. Previous history of esophagectomy or mediastinal surgery 4. Previous history of endoscopic resection for early esophageal cancers, including endoscopic mucosal resection and endoscopic submucosal dissection 5. End-stage Achalasia with dilated esophagus more than 6cm on Barium swallow Investigations before and after POEM
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dysphagia score | — |
Secondary
| Measure | Time frame |
|---|---|
| Eckhart score | — |
| Operative time | — |
| Improvement in LES pressure | — |
| Time to resume diet | — |
| Morbidities | — |
| Length of myotomy | — |
Countries
Hong Kong
Contacts
Primary ContactPhilip WY Chiu, MD
Outcome results
None listed