Depth of Anesthesia in Cardiac Surgery

Monitoring of Anesthetic Depth During Surgical Correction of Acquired Valvular Disorders

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01524354

Enrollment

Registered

2012-02-01

Start date

2010-03-31

Completion date

2011-12-31

Last updated

2012-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Valve Diseases

Keywords

depth of anesthesia, valve surgery

Brief summary

The aim of our study was to evaluate the significance of monitoring anesthetic depth for the conduct of anesthesia and the early postoperative period in patients subjected to surgical correction of combined valvular disorders.

Detailed description

Our aim was to evaluate the effect of monitoring anesthetic depth on duration of postoperative mechanical ventilation and ICU stay after surgical correction of combined valvular disorders.

Interventions

PROCEDUREmaintenance of anesthesia

intraoperative maintenance of anesthesia with propofol under control of cerebral state index at 40-60 points

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* requirement of surgical correction of two or more valves

Exclusion criteria

* no

Design outcomes

Primary

Measure	Time frame	Description
duration of postoperative mechanical ventilation	24 hours postoperatively	Criteria for termination of postoperative respiratory support were the following: patient able to cooperate; adequate muscular tone; SpO2 \> 95% with FiO2 0.5; PaCO2 \< 45 mm Hg; postoperative bleeding rate \< 50 mL hr-1; stable hemodynamics without inotropic/vasopressor support; body temperature of \> 35 °C. Temporary pacing was not regarded as a contraindication for tracheal extubation.

Secondary

Measure	Time frame	Description
length of ICU stay	7 days postoperatively	The time until 'fit for ICU discharge' criteria as well as the actual length of the ICU stay were registered. The 'fit for ICU discharge' criteria included the following: fully oriented patient, SaO2 \> 90% on room air, no episodes of severe arrhythmias, bleeding \< 50 mL hr-1, diuresis \> 0.5 mL kg-1 hr-1, no need for inotropic/vasopressor support and no signs of ischemia on ECG.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026